Table 2 Association analysis in the 1,693 T1D patients and 1,805 controls from the UK.
From: Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11
Gene | Allele | Type 1 diabetes patients | Controls | MAF | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Polymorphism | 1/2 | 11 (%) | 12 (%) | 22 (%) | 11 (%) | 12 (%) | 22 (%) | T1D | Controls | OR for allele 1 (95% CI) | P-value |
PAPD1 | |||||||||||
rs2480285 | G/A | 82 (5.0) | 544 (33.4) | 1002 (61.5) | 59 (3.4) | 600 (34.9) | 1060 (61.7) | 0.22 | 0.21 | 1.05 (0.94 – 1.18) | 0.39 |
ss48399025 | A/C | 1375 (81.4) | 296 (17.5) | 19 (1.1) | 1469 (81.4) | 326 (18.1) | 10 (0.6) | 0.10 | 0.1 | 0.97 (0.83 – 1.13) | 0.68 |
ss48399034 | A/T | 1528 (90.6) | 155 (9.2) | 3 (0.2) | 1620 (92.3) | 133 (7.6) | 2 (0.1) | 0.05 | 0.04 | 0.81 (0.64 – 1.02) | 0.076 |
ss48399036 | A/G | 0 (0.0) | 64 (3.8) | 1629 (96.2) | 0 (0.0) | 60 (3.3) | 1734 (96.7) | 0.02 | 0.02 | 1.13 (0.79 – 1.62) | 0.49 |
rs1963187 | A/T | 1457 (89.1) | 170 (10.4) | 8 (0.5) | 1564 (89.6) | 175 (10.0) | 7 (0.4) | 0.06 | 0.05 | 0.95 (0.77 – 1.17) | 0.62 |
D10S193 | 226/non 226 | 21 (1.3) | 293 (18.5) | 1270 (80.2) | 15 (1.0) | 261 (16.6) | 1297 (82.5) | 0.11 | 0.09 | 1.16 (0.98 – 1.37) | 0.078 |
D10S193 | 228/non 228 | 4 (0.3) | 158 (10.0) | 1422 (89.8) | 13 (0.8) | 195 (12.4) | 1365 (86.8) | 0.05 | 0.07 | 0.73 (0.59 – 0.90) | 0.0031 |
NRP1 | |||||||||||
rs1048804 | A/G | 962 (57.7) | 605 (36.3) | 100 (6.0) | 1068 (59.9) | 636 (35.7) | 80 (4.5) | 0.24 | 0.22 | 0.9 (0.81 – 1.01) | 0.071 |
MYO3A | |||||||||||
rs1339816 | A/G | 183 (11.3) | 686 (42.3) | 751 (46.4) | 190 (11.2) | 731 (43.1) | 774 (45.7) | 0.32 | 0.33 | 0.99 (0.89 – 1.09) | 0.79 |
rs2096176 | A/G | 312 (18.7) | 790 (47.2) | 570 (34.1) | 310 (17.5) | 872 (49.1) | 593 (33.4) | 0.42 | 0.42 | 1.01 (0.92 – 1.11) | 0.83 |
HNRPF | |||||||||||
rs1416226 | A/G | 101 (6.1) | 574 (34.4) | 993 (59.5) | 91 (5.2) | 629 (36.0) | 1028 (58.8) | 0.23 | 0.23 | 1.0 (0.90 – 1.12) | 0.95 |
SVIL | |||||||||||
rs2274494 | A/G | 230 (13.7) | 784 (46.9) | 659 (39.4) | 214 (12.2) | 847 (48.2) | 698 (39.7) | 0.37 | 0.36 | 1.04 (0.94 – 1.15) | 0.42 |
rs11600 | T/C | 32 (1.9) | 372 (22.3) | 1261 (75.7) | 25 (1.4) | 397 (22.3) | 1362 (76.3) | 0.13 | 0.13 | 1.05 (0.91 – 1.21) | 0.48 |
Intergenic | |||||||||||
rs787025 | T/G | 8 (0.5) | 226 (13.6) | 1433 (86.0) | 6 (0.3) | 237 (13.2) | 1549 (86.4) | 0.07 | 0.07 | 1.05 (0.87 – 1.26) | 0.62 |