X chromosome transmission ratio distortion in Cftr +/- intercross-derived mice

BMC Genomic Data

Table 2 DXMit16 Genotype frequency in 3 week old CF and non-CF mice of replicate studies

	dataset	No. mice	No. B6:B6	No. B6:BALB	No. BALB:BALB	P-value^c
F2 Non-CF 3 weeks
Females	Present^a	687	210	188	289	3.0 × 10^-35
	HSC^b	45	5	23	17	0.04
	total	732	215	211	306	3.8 × 10^-34
Males	Present	341	154^d	0	187	0.05
	HSC	51	17	0	34	7.6 × 10^-4
	total	392	171	0	221	0.012
F2 CF 3 weeks
Females	Present	56	14	31	11	0.62
	HSC	134	32	75	27	0.32
	total	190	46	106	38	0.20
Males	Present	79	34	0	45	0.22
	HSC	126	79	0	47	5.5 × 10^-5
	total	205	113	0	92	0.14

^aPresent data set; ^bData taken from Haston & Tsui 2003, from the Hospital for Sick Children.
^cP-values obtained by standard Pearson's χ² test comparing observed values to expected 1:2:1 ratio (B6/B6:B6/BALB:BALB/BALB) of genotypes, (except for 1:1 X chromosome genotypes of male mice). B6 = C57BL/6J, BALB = BALB/cJ.
^dDXMit16 genotype is B6 or BALB in male mice.

ISSN: 2730-6844