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Table 2 DXMit16 Genotype frequency in 3 week old CF and non-CF mice of replicate studies

From: X chromosome transmission ratio distortion in Cftr +/- intercross-derived mice

  dataset No. mice No. B6:B6 No. B6:BALB No. BALB:BALB P-valuec
F2 Non-CF 3 weeks
Females Presenta 687 210 188 289 3.0 × 10-35
  HSCb 45 5 23 17 0.04
  total 732 215 211 306 3.8 × 10-34
Males Present 341 154d 0 187 0.05
  HSC 51 17 0 34 7.6 × 10-4
  total 392 171 0 221 0.012
F2 CF 3 weeks
Females Present 56 14 31 11 0.62
  HSC 134 32 75 27 0.32
  total 190 46 106 38 0.20
Males Present 79 34 0 45 0.22
  HSC 126 79 0 47 5.5 × 10-5
  total 205 113 0 92 0.14
  1. aPresent data set; bData taken from Haston & Tsui 2003, from the Hospital for Sick Children.
  2. cP-values obtained by standard Pearson's χ2 test comparing observed values to expected 1:2:1 ratio (B6/B6:B6/BALB:BALB/BALB) of genotypes, (except for 1:1 X chromosome genotypes of male mice). B6 = C57BL/6J, BALB = BALB/cJ.
  3. dDXMit16 genotype is B6 or BALB in male mice.
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