Figure 3

Human MHC class I map showing known polymorphic genes. Distances are drawn to scale (see legend), but these may vary at many locations in different haplotypes as a result of limited polymorphic DNA insertions, deletions or gene duplications. Two non-classical polymorphic candidate genes (white text boxes), RNF39 (ring finger protein 39) and TRIM10 (tripartite motif-containing 10), are located between the HLA-type genes (gray text boxes) HLA-A and HLA-E, while other polymorphic genes are located between HLA-E and HLA-C: CDSN (corneodesmosin), IER3 (immediate early response 3), MDC1 (mediator of DNA damage checkpoint 1), PPP1R10 (protein phosphatase 1, regulatory inhibitor subunit 10) and GNL1 (guanine nucleotide binding protein-like 1). Gene locations are drawn to scale and were taken from the Sanger Institute MHC list for the COX cell line [41] and the distance (in megabases (Mb)) from HLA*B at the centromeric (C) end to an arbitrary point telomeric (T) to HLA-A are shown.