DNA repair gene XRCC1 polymorphisms and bladder cancer risk

BMC Genomic Data

Table 1 The linkage disequilibrium (LD) between all 14 XRCC1 polymorphisms

No	Polymorphisms	1	2	3	4	5	6	7	8	9	10	11	12	13	14
1	EX1-1139 D' (r2)	*0.20 (0.13)*
2	EX1-1128	0.82 (0.57)	*0.22 (0.13* )
3	EX1-900	0.92 (0.30)	0.98 (0.39)	*0.41 (0.22)*
4	EX-128	0.89 (0.27)	0.95 (0.35)	1 (0.93)	*0.42 (0.22)*
5	EX-52	1 (0.01)	1 (0.01)	1 (0.02)	0.68 (0.02)	*0.03 (0.02)*
6	Val72Ala	N/A	N/A	N/A	N/A	N/A	*0 (0.03)*
7	Arg194Trp	1 (0.02)	1 (0.02)	0.97 (0.04)	0.97 (0.04)	1 (0)	N/A	*0.06 (0.12)*
8	IVS7-33	0.04 (0)	0.05 (0)	0.06 (0)	0.06 (0)	0.15 (0)	N/A	0.13 (0)	*0.46 (0.11)*
9	Pro206Pro	0.89 (0.24)	0.96 (0.32)	1 (0.83)	0.97 (0.83)	0.39 (0.01)	N/A	0.98 (0.05)	0.06 (0)	*0.44 (0.26)*
10	Arg280His	0.65 (0)	0.93 (0.01)	0.79 (0.02)	0.74 (0.02)	1 (0)	N/A	1 (0)	1 (0.04)	0.70 (0.02)	*0.04 (0.10)*
11	Arg399Gln	0.87 (0.11)	0.93 (0.14)	1 (0.39)	0.96 (0.39)	0.04 (0)	N/A	1 (0.04)	0.08 (0)	0.99 (0.47)	1 (0.03)	*0.37 (0.23)*
12	Gln632Gln	0.86 (0.24)	0.95 (0.32)	0.99 (0.84)	0.91 (0.77)	1 (0.02)	N/A	0.91 (0.04)	0.06 (0)	0.97 (0.90)	0.61 (0.01)	1 (0.45)	*0.56 (0.29)*
13	EX17-123	0.69 (0.01)	0.76 (0.01)	0.86 (0.03)	0.92 (0.03)	1 (0)	N/A	1 (0)	0 (0)	0.94 (0.04)	0.82 (0)	0.98 (0.03)	0.88 (0.04)	*0.06 (0.13* )
14	EX17-127	0.69 (0.03)	0.75 (0.04)	0.95 (0.33)	0.96 (0.32)	1 (0.01)	N/A	0.77 (0.01)	0.08 (0)	1 (0.30)	1 (0.01)	1 (0.16)	0.99 (0.31)	0.11 (0)	*0.21 (0.09)*

Values in bold italics represent the observed followed by estimated (in round bracket) control minor allele frequencies from public databases.
* LD is presented in pairwise D' followed by r² in round bracket.
N/A = Not available because of no pairwise variant genotypes in rare polymorphisms.
Values in bold are polymorphisms in high LD (D' ≥ 0.90and r2 ≥ 0.80).

ISSN: 2730-6844