Figure 1

Phenotype-genotype association (PGA) grid. Top Panel: Phenotype-Genotype Association Grip for SNP rs275649. 144 tests of association are displayed in color-coded cells. Colors indicate level of statistical significance: blue p ≥ 0.05, green 0.01 ≤ P < 0.05, yellow 0.001 ≤ P < 0.01, orange 0.0001 ≤ P < 0.001, red P < 0.0001. (Tests with fewer than 10 participants for a genotype are identified by an asterisk to alert the user that the estimates may be unstable. That was not the case for this example.) Bottom Panel: Least Squares Means Plot of Left Ventricular Fractional Shortening by Genotype Mean values (and standard errors) for left ventricular fractional shortening, by genotype for SNP rs275649, based on a general model that adjusted for age and sex in the pooled sample of men and women (p = 3.8 × 10⁵). (Tests with fewer than 10 participants for a genotype are identified by cross-hatching of corresponding bars to alert the user that the estimates may be unstable. That was not the case for this example.)