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Table 1 Characteristics of study participants by genotype for PONS1 Q192R polymorphism (N = 3,266)

From: The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis

Variable Means or [N] % (95% CI) by genotype P heterogeneitya
  QQ N = 1669 QR N = 1326 RR N = 271  
Dichotomous variables
Myocardial infarction (MI) [53] 3.2 (2.4, 4.3) [46] 3.5 (2.6, 4.8) [12] 4.4 (2.3, 7.6) 0.51
Angina (but no history of MI) [186] 11.1 (9.7, 12.8) [165] 12.4 (10.7, 14.3) [18] 6.6 (4.0, 10.3) 0.13
Any CHD (MI or angina) [239] 14.3 (12.7, 16.1) [211] 15.9 (14.1, 18.0) [30] 11.1 (7.6, 15.4) 0.14
Diabetes at baseline [75] 4.5 (3.6, 5.6) [70] 5.3 (4.3, 6.7) [12] 4.4 (2.5, 7.6) 0.61
Current smoker [189] 11.3 (9.9, 12.9) [163] 12.3 (10.6, 14.1) [22] 8.1 (5.4, 11.9) 0.12
Ever smoker [746] 44.6 (42.2, 47.0) [596] 44.9 (42.3, 47.6) [116] 42.9 (37.1, 48.8) 0.82
Adult manual social class [964] 57.8 (55.4, 60.2) [725] 54.7 (52.0, 57.3) [157] 57.9 (51.9, 63.6) 0.20
Childhood manual social class [1334] 79.9 (77.9, 81.8) [1075] 81.1 (78.9, 83.1) [219] 81.0 (75.9, 85.2) 0.72
On statin [126] 7.5 (6.4, 8.9) [95] 6.9 (5.6, 8.3) [25] 9.2 (6.3, 13.2) 0.41
Continuous variables
Age 68.8 (68.6, 69.1) 68.8 (68.5, 69.1) 68.9 (68.3, 68.3) 0.91
HOMAc 1.64 (1.59, 1.70) 1.72 (1.66, 1.79) 1.69 (1.56, 1.82) 0.15
Total cholesterol 6.64 (6.58, 6.70) 6.65 (6.58, 6.72) 6.61 (6.46, 6.75) 0.85
HDLc 1.65 (1.63, 1.67) 1.65 (1.63, 1.68) 1.70 (1.65, 1.76) 0.18
LDLc 4.15 (4.09, 4.20) 4.15 (4.09, 4.21) 4.02 (3.89, 4.16) 0.21
Triglyceridesc 1.67 (1.64, 1.71) 1.69 (1.65, 1.73) 1.71 (1.62, 1.81) 0.73
Systolic BP 148.3 (147.1, 149.5) 146.0 (144.6, 147.3) 150.4 (147.4, 153.4) 0.006
Diastolic BP 79.9 (79.3, 80.4) 78.9 (78.3, 79.6) 80.3 (78.9, 81.8) 0.05
BMI 27.6 (27.3, 27.8) 27.6 (27.4, 27.9) 27.6 (27.0, 28.2) 0.96
WHR 0.817 (0.814, 0.821) 0.821 (0.817, 0.824) 0.826 (0.818, 0.834) 0.11
  1. a χ2 for dichotomous variables and ANOVA for continuous variables bOccurrence of a new CHD event (death from CHD, new diagnosis of MI / angina, new CABG or angioplasty). All other characteristics are from baseline measures cGeometric means