Skip to main content

Table 1 Segregation Analysis Results for Three Age-at-onset Traits. Recessive Trait Parameter Estimates (S.E.) from Proportional Hazards Models(GAP) and Regressive Threshold Models (REGRESS)

From: Using an age-at-onset phenotype with interval censoring to compare methods of segregation and linkage analysis in a candidate region for elevated systolic blood pressure

  Parameter
  Two Covariates Five Covariates
Model UpperA Mid-pointB LowerC UpperA Mid-pointB LowerC
Proportional Hazards       
   Allele Frequency 0.76(.05) 0.78(.05) 0.81(.05)    
   Major GeneD 1.40(.13) 1.41(.14) 1.37(.15)    
   SexE 0.23(.07) 0.23(.06) 0.22(.06)    
   CohortF 0.52(.07) 0.52(.06) 0.53(.06)    
-logL 6728 6764 6867    
Regressive Threshold       
   Allele Frequency 0.50 0.55 0.52 0.55 0.51 0.51
   Major GeneD 0.96 0.83 0.60 1.52 1.32 1.74
   SexE 0.29 0.29 0.21 0.11 0.10 0.01
   CohortF 0.01 0.01 -0.08 -0.02 0.01 -0.08
   BMIG     0.05 0.05 0.05
   SmokingH     0.02 0.02 0.05
   DrinkingI     0.01 0.01 0.01
   Parent-offspring corr 0.15 0.13 0.16 0.16 0.11 0.12
   Sib-Sib corr 0.00 0.00 0.16 0.08 0.06 0.10
-logL 6558 6679 6600 6477 6604 6537
  1. AUpper value from age interval. BValue at midpoint of interval. CLower value from age interval. DMajor gene effect is measured by the displacement (see Methods). E Sex variable (female vs. male). FCohort variable (offspring vs. original). GBody mass index (weight/height2 in kg/m2). HDaily cigarette consumption. IDaily alcohol consumption (g/day).
\