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Table 3 Comparison of linkage results for subjects in G2 (R4) versus in G3 (R1 and R2)

From: An autosome-wide search using longitudinal data for loci linked to type 2 diabetes progression

Ch # Phenotype Group Rate: Age Location Distance (cM) Most Significant Marker Most Significant P-value  
1 R4G2: 43–47 q25 ~ q32 176 ~ 218 GATA48B01 A 5.21 × 10 -8  
  R2G3: 51–55 p31.1 ~ p22.1 114 ~ 137 ATA29D04 0.0074  
  G3 – Mean p31.1 ~ p22.1 114 ~ 140 ATA2E04 0.0074  
3 R4G2: 43–47 p26.3 ~ p21.31 6 ~ 71 GATA164B08 1 × 10 -11  
  G3 – Mean p14.1 ~ q12.3 91 ~ 119 GATA128C02 0.0049  
8 R4G2: 43–47 q23.1 ~ q24.13 119 ~ 135 GATA7G07 2.94 × 10 -6  
  R1G3: 43–51 q24.13 ~ q24.22 135 ~ 148 GATA21C12 0.0025  
  R2G3: 51–55 q24.13 ~ q24.22 135 ~ 148 GATA21C12 B 1.06 × 10 -4  
9 R4G2: 43–47 p24.1 ~ p21.3 14 ~ 44 GATA27A11 7.0 × 10 -7  
11 R4G2: 43–47 p15.5 ~ p15.2 2 ~ 21 GATA23F06 9.9 × 10-4  
   q22.3 ~ q24.3 101 ~ 131 GATA23E06 3.14 × 10 -4  
  G2 – Mean q12.1 ~ q13.5 56 ~ 76 GATA90D07 0.0090  
  G3 – Mean Glucose p14.1 ~ q12.3 91 ~ 119 GATA30G01 6.6 × 10 -4  
18 R4G2: 43–47 p11.31 ~ q22.1 13 ~ 107 GATA26C03 < 10 -11  
  R1G3: 43–51 p11.31 3 ~ 7 321xc9 0.007  
  R2G3: 51–55 q21.2 ~ q21.32 80 ~ 89 ATA7D07 0.0059  
  1. ABold p-values indicate statistically significant evidence for linkage. BItalicized p-values are suggestive evidence for linkage by conventional criteria [9]; marker range in the table corresponds to p-values < 0.01.