Analysis of gene × environment interactions in sibships using mixed models

BMC Genomic Data

Table 2 Adjusted fixed effects estimates and standard errors from the gene × environment model

	FULL DATA-ADJ2^A			FULL DATA-ADJ1^B			ONE SIBSHIP DATA-ADJ1 (100 random draws)^C
Effect	Estimate	SE	P-value (t-test)	Estimate	SE	P-value (t-test)	Avg Estimate	Avg SE	Avg P-value (t-test)
Intercept	95.72	6.91	<0.0001	95.99	6.90	<0.0001	87.67	7.81	<0.0001
Gender	-10.71	1.89	<0.0001	-9.98	2.07	<0.0001	-4.71	2.32	0.0001
Baseline age	0.15	0.14	0.29	0.19	0.14	0.18	0.16	0.16	0.36
BMI	0.49	0.16	0.003	0.51	0.16	0.002	0.63	0.18	0.001
Hypertensive treatment	-2.44	4.55	0.59	-3.32	4.60	0.47	-0.20	5.34	0.68
Cigarettes per day	0.11	0.05	0.04	0.13	0.05	0.02	0.10	0.06	0.11
Grams of alcohol per day	0.07	0.01	<0.0001	0.06	0.01	<0.0001	0.06	0.01	<0.0001
Marker GATA48G07A	5.49	2.24	0.01	4.04	2.07	0.05	2.84	2.33	0.02
Baseline age and gender	-0.19	0.06	0.0005	-0.17	0.06	0.006	-0.16	0.07	0.03
Baseline age and cigarettes per day	-0.005	0.002	0.003	-0.005	0.002	0.001	-0.004	0.002	0.01
Baseline age and hypertensive treatment	0.14	0.07	0.04	0.13	0.07	0.06	0.19	0.08	0.03
Baseline age and BMI	0.02	0.005	0.0005	0.02	0.005	0.001	0.02	0.006	0.008
Hypertensive treatment and BMI	-0.29	0.12	0.01	-0.30	0.12	0.01	-0.26	0.13	0.07
Baseline age and marker GATA48G07A	0.14	0.07	0.04	0.11	0.06	0.08	0.16	0.07	0.03

^AFULL DATA-ADJ2: full data set using all available sibships adjusting for both levels of nesting (sibs within sibships and sibships within pedigrees); ^BFULL DATA-ADJ1: full data set using all available sibships adjusting for one level of nesting (sibs within sibships); ^CONE SIBSHIP DATA-ADJ1 (100 random draws): data set using one randomly drawn sibship per each extended pedigree, adjusting for one level of nesting (sibs within sibships) performed 100 times.

ISSN: 2730-6844