Skip to main content

Table 6 Logarithm triglyceride vs. HDL cholesterol ratio: Class D regressive models, conditional on proband phenotypes

From: Consistency of genetic inheritance mode and heritability patterns of triglyceride vs. high density lipoprotein cholesterol ratio in two Taiwanese family samples

I. Community-based:
Model Sporadic Pure familial correlation, i.e. polygenic Environmental + familial correlation Pure major gene (Mendel) Mendel + familial correlation Unrestricted, general
  Parameter S.E. Parameter S.E. Parameter S.E. Parameter S.E. Parameter S.E. Parameter S.E.
qA [1]   [1]   0.190 0.035 0.251 0.035 0.264 0.045 0.203 0.049
τAA -   -   =qA   [1]   [1]   0.266 0.144
τAB -   -   =qA   [0.5]   [0.5]   0.431 0.125
τBB -   -   =qA   [0]   [0]   0.044 0.073
μAA 0.864 0.024 0.903 0.043 2.450 0.170 2.363 0.162 2.316 0.196 2.514 0.227
μAB AA  AA   1.281 0.082 1.149 0.074 0.971 0.165 1.326 0.130
μBB AA  AA   0.555 0.057 0.560 0.035 0.651 0.095 0.554 0.075
σ2 0.400 0.021 0.465 0.038 0.239 0.029 0.209 0.016 0.276 0.040 0.202 0.027
ρMF [0]   0.041 0.071 0.028 0.125 -0.026 0.106 0.062 0.106 0.058 0.138
ρMO [0]   0.401 0.067 0.555 0.114 [0]   0.284 0.077 0.286 0.318
ρFO [0]   0.184 0.068 0.394 0.101 [0]   0.150 0.134 0.212 0.154
ρSS [0]   0.513 0.067 0.643 0.084 [0]   0.332 0.085 0.457 0.257
# 2   6   9   6   9   12  
-2ln(L) 1372.22   1308.95   1260.71   1279.92   1266.27   1252.03  
υ2 120.19   56.92   8.68   27.89   14.24    
Degree of freedom 10   6   3   6   3    
P value 0.000   0.000   0.034   0.000   0.003   Baseline  
AIC 1376.22   1320.95   1278.71   1291.92   1284.27   1276.03  
II. Hospital based,
Model Sporadic Pure familial correlation, i.e. polygenic Environmental + familial correlation Pure major gene (Mendel) Mendel + familial correlation Unrestricted, general
  Parameter S.E. Parameter S.E. Parameter S.E. Parameter S.E. Parameter S.E. Parameter S.E.
qA [1]   [1]   0.232 0.060 0.368 0.036 0.290 0.028 0.369 0.036
τAA -   -   =qA   [1]   [1]   0.598 0.277
τAB -   -   =qA   [0.5]   [0.5]   0.181 0.097
τBB -   -   =qA   [0]   [0]   0.756 0.099
μAA 0.801 0.019 0.801 0.020 1.997 0.125 1.751 0.077 1.953 0.098 1.727 0.062
μAB AA  AA   1.215 0.134 0.396 0.016 0.289 0.040 0.396 0.014
μBB AA  AA   0.443 0.076 0.945 0.029 1.036 0.032 0.944 0.020
σ2 0.459 0.018 0.458 0.018 0.246 0.031 0.259 0.018 0.211 0.023 0.251 0.018
ρMF [0]   0.160 0.043 0.292 0.081 0.247 0.001 [0]   0.247 0.001
ρMO = ρFO = ρSS [0]   0.320 0.072 0.579 0.090 0.735 0.000 [0]   0.735 0.000
# 2   4   7   7   5   10  
-2ln(L) 2690.30   2662.03   2637.51   2637.78   2665.49   2625.11  
Degree of freedom 8   6   3   3   5    
P 0.000   0.000   0.000   0.006   0.005   Baseline  
AIC 2694.3   2670.03   2651.51   2651.78   2675.49   2645.11  
  1. Abbreviation: #, number of parameters; SEM, standard error of mean; qA, gene frequency; τAA, τAB, τBB, transmission probability; μAA, μAB, μBB, genotype means; σ2, variance; ρMF, ρMO, ρFO, ρSS, correlation coefficients among spouse, mother-offspring, father-offspring and sibling pairs; #, number of parameters; ln(L), logarithm of likelihood; AIC, Akaike information criteria; P, significance level compared with the unrestricted general model.