I. Community-based: | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Model | Sporadic | Pure familial correlation, i.e. polygenic | Environmental + familial correlation | Pure major gene (Mendel) | Mendel + familial correlation | Unrestricted, general | ||||||
Parameter | S.E. | Parameter | S.E. | Parameter | S.E. | Parameter | S.E. | Parameter | S.E. | Parameter | S.E. | |
qA | [1] | [1] | 0.190 | 0.035 | 0.251 | 0.035 | 0.264 | 0.045 | 0.203 | 0.049 | ||
τAA | - | - | =qA | [1] | [1] | 0.266 | 0.144 | |||||
τAB | - | - | =qA | [0.5] | [0.5] | 0.431 | 0.125 | |||||
τBB | - | - | =qA | [0] | [0] | 0.044 | 0.073 | |||||
μAA | 0.864 | 0.024 | 0.903 | 0.043 | 2.450 | 0.170 | 2.363 | 0.162 | 2.316 | 0.196 | 2.514 | 0.227 |
μAB | =μAA | =μAA | 1.281 | 0.082 | 1.149 | 0.074 | 0.971 | 0.165 | 1.326 | 0.130 | ||
μBB | =μAA | =μAA | 0.555 | 0.057 | 0.560 | 0.035 | 0.651 | 0.095 | 0.554 | 0.075 | ||
σ2 | 0.400 | 0.021 | 0.465 | 0.038 | 0.239 | 0.029 | 0.209 | 0.016 | 0.276 | 0.040 | 0.202 | 0.027 |
ρMF | [0] | 0.041 | 0.071 | 0.028 | 0.125 | -0.026 | 0.106 | 0.062 | 0.106 | 0.058 | 0.138 | |
ρMO | [0] | 0.401 | 0.067 | 0.555 | 0.114 | [0] | 0.284 | 0.077 | 0.286 | 0.318 | ||
ρFO | [0] | 0.184 | 0.068 | 0.394 | 0.101 | [0] | 0.150 | 0.134 | 0.212 | 0.154 | ||
ρSS | [0] | 0.513 | 0.067 | 0.643 | 0.084 | [0] | 0.332 | 0.085 | 0.457 | 0.257 | ||
# | 2 | 6 | 9 | 6 | 9 | 12 | ||||||
-2ln(L) | 1372.22 | 1308.95 | 1260.71 | 1279.92 | 1266.27 | 1252.03 | ||||||
υ2 | 120.19 | 56.92 | 8.68 | 27.89 | 14.24 | |||||||
Degree of freedom | 10 | 6 | 3 | 6 | 3 | |||||||
P value | 0.000 | 0.000 | 0.034 | 0.000 | 0.003 | Baseline | ||||||
AIC | 1376.22 | 1320.95 | 1278.71 | 1291.92 | 1284.27 | 1276.03 | ||||||
II. Hospital based, | ||||||||||||
Model | Sporadic | Pure familial correlation, i.e. polygenic | Environmental + familial correlation | Pure major gene (Mendel) | Mendel + familial correlation | Unrestricted, general | ||||||
Parameter | S.E. | Parameter | S.E. | Parameter | S.E. | Parameter | S.E. | Parameter | S.E. | Parameter | S.E. | |
qA | [1] | [1] | 0.232 | 0.060 | 0.368 | 0.036 | 0.290 | 0.028 | 0.369 | 0.036 | ||
τAA | - | - | =qA | [1] | [1] | 0.598 | 0.277 | |||||
τAB | - | - | =qA | [0.5] | [0.5] | 0.181 | 0.097 | |||||
τBB | - | - | =qA | [0] | [0] | 0.756 | 0.099 | |||||
μAA | 0.801 | 0.019 | 0.801 | 0.020 | 1.997 | 0.125 | 1.751 | 0.077 | 1.953 | 0.098 | 1.727 | 0.062 |
μAB | =μAA | =μAA | 1.215 | 0.134 | 0.396 | 0.016 | 0.289 | 0.040 | 0.396 | 0.014 | ||
μBB | =μAA | =μAA | 0.443 | 0.076 | 0.945 | 0.029 | 1.036 | 0.032 | 0.944 | 0.020 | ||
σ2 | 0.459 | 0.018 | 0.458 | 0.018 | 0.246 | 0.031 | 0.259 | 0.018 | 0.211 | 0.023 | 0.251 | 0.018 |
ρMF | [0] | 0.160 | 0.043 | 0.292 | 0.081 | 0.247 | 0.001 | [0] | 0.247 | 0.001 | ||
ρMO = ρFO = ρSS | [0] | 0.320 | 0.072 | 0.579 | 0.090 | 0.735 | 0.000 | [0] | 0.735 | 0.000 | ||
# | 2 | 4 | 7 | 7 | 5 | 10 | ||||||
-2ln(L) | 2690.30 | 2662.03 | 2637.51 | 2637.78 | 2665.49 | 2625.11 | ||||||
Degree of freedom | 8 | 6 | 3 | 3 | 5 | |||||||
P | 0.000 | 0.000 | 0.000 | 0.006 | 0.005 | Baseline | ||||||
AIC | 2694.3 | 2670.03 | 2651.51 | 2651.78 | 2675.49 | 2645.11 |