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Table 3 Expected rates of false positive results and expected positive predictive values for differentRHD PCR strategies*

From: RHD positive haplotypes in D negative Europeans

  Rate of Positive predictive value Number of
PCR strategy false positives of positive result polymorphism tested
Exon 10 only [1,2] 1:1,276 0.999216 1
Intron 4/Exon 7 [13] 1:4,081 0.999755 2
Intron 4/Exon 7/RHDψ [14] 1:4,700 0.999787 3
Intron 4/Exon 7/W16X 1:5,212 0.999808 3
Intron 4/Exon 7/Intron 7 1:6,051 0.999835 3
Exons 3, 4, 5, 6, 7, 9 [26] 1:6,051 0.999835 6
Exons 2, 3, 4, 5, 6, 7, 9, 10 [27] 1:6,051 0.999835 8
Intron 4/Exon 7/W16X/RHDψ 1:6,267 0.999840 4
All Exons/RHDψ 1:7,520 0.999867 9
Intron 4/Exon 7/Intron 7/W16X 1:8,921 0.999888 4
Intron 4/Exon 7/Intron 7/W16X/RHDψ 1:12,533 0.999920 5
  1. * Rates were calculated based on the population frequencies of different alleles determined in the Table 2. The exact rates are population dependent and may vary according to the prevalence of alleles in the population tested.
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