Skip to main content

Table 3 Hardy Weinberg equilibrium and LD variance for the three EAAT2 SNPs using pyrosequencing or SSCP

From: Detection of three closely located single nucleotide polymorphisms in the EAAT2 promoter: comparison of single-strand conformational polymorphism (SSCP), pyrosequencing and Sanger sequencing

  Pyrosequencing SSCP
  Hardy-Weinberg
for -168 p > 0.99 N/A
for -181 p = 0.0188 p = 0.4063
for -200 p = 0.0256 p = 0.3325
  Lewontin’s D’
-168 and -181 0.49 N/A
-168 and -200 1 N/A
-181 and -200 0.94 1
  r 2
-168 and -181 0 N/A
-168 and -200 0 N/A
-181 and -200 0.79 0.99
  1. Lewontin’s D’ and r2 both give ordinal measures of Linkage Disequilibrium (LD). Please note only one mutation was found at -168 making interpretation difficult for these associations.
\