Table 4 Univariate and multivariate cox proportional hazard model for the survival of breast cancer patients
Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Â | Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P |
Tumor size (large vs small) | 2.4 | 1.2-4.9 | 0.019 | Â | Â | Â |
Lymph node status (pos. vs neg.) | 4.9 | 2.4-9.8 | 0.0001 | 4.0 | 1.6 - 9.9 | 0.003 |
Histological grade (poor vs well) | 2.1 | 1.1-4.0 | 0.033 | Â | Â | Â |
Stage (III vs I/II) | 3.2 | 1.7-5.9 | 0.0001 | Â | Â | Â |
HER2 status (amp. vs wildtype) | 2.2 | 1.1-4.2 | 0.022 | Â | Â | Â |
TP53 (mutant vs wildtype) | 2.3 | 1.2-4.3 | 0.012 | Â | Â | Â |
Tumor tissue PTPRO methylation (yes vs no) | 3.8 | 1.9-7.5 | 0.0001 | 2.7 | 1.1- 6.2 | 0.023 |
ER + group tumor tissue PTPRO methylation (yes vs no) | 3.9 | 1.7-8.7 | 0.001 | 2.8 | 1.0-8.4 | 0.060 |
PR + group tumor tissue PTPRO methylation (yes vs no) | 3.1 | 1.2-7.4 | 0.012 | 3.2 | 0.8-11.9 | 0.091 |
HER2+ group tumor tissue PTPRO methylation (yes vs no) | 5.0 | 1.8-16.8 | 0.010 | 7.5 | 1.8-31.3 | 0.006 |