Table 5 Details of the SCNN1 gene family members and SNPs selected
Gene | Gene location | No. of SNPs1 | SNP rs#. | SNP location (Chr: bp) | Mutations type | Major allele (Fre)2 |
|---|---|---|---|---|---|---|
SCNN1a | chr1: 80,034,908-80,045,394 | 2 | rs14845039 | 1:80035441 | Synonymous coding (C/T) | T(0.71) |
| Â | Â | rs13886292 | 1:80039016 | Intronic (G/C) | G(0.82) | |
SCNN1b | chr14: 7,002,221-7,011,192 | 6 | rs13532836 | 14:7005977 | Intronic (A/G) | C(0.74) |
| Â | Â | rs13532838 | 14:7007309 | Synonymous coding (A/G) | T(0.51) | |
|  |  | rs14075350 | 14:7011699 | 5’UTR (C/T) | C(0.68) | |
| Â | Â | Â | rs13532842 | 14:7011842 | Intronic (A/G) | A(0.64) |
| Â | Â | Â | rs15731904 | 14:7003218 | Intronic (A/G) | G(1.00) |
| Â | Â | Â | rs15731913 | 14:7006347 | Intronic (C/G) | NA |
SCNN1d | chr21: 2,435,983- 2,440,820 | 4 | rs14282978 | 21:2436106 | Synonymous coding (C/T) | T(0.95) |
| Â | Â | rs15181931 | 21:2438805 | Intronic (T/G) | C(0.72) | |
|  |  | rs15181934 | 21:2442772 | 5’UTR (G/A) | T(0.57) | |
| Â | Â | Â | rs14282986 | 21:2437824 | Intronic (A/G) | T(0.70) |
SCNN1g | chr14: 7,019,365- 7,028,441 | 7 | rs10730783 | 14:7018929 | 3’UTR (A/G) | G(0.82) |
|  |  | rs15009191 | 14:7019233 | 3’UTR (A/G) | C(0.83) | |
| Â | Â | rs15009198 | 14:7022273 | Intronic (A/G) | C(0.77) | |
| Â | Â | Â | rs15009204 | 14:7023020 | Intronic (A/C) | T(0.57) |
| Â | Â | Â | rs15009207 | 14:7027589 | Intronic (A/G) | T(0.56) |
| Â | Â | Â | rs15009209 | 14:7027788 | Intronic (A/G) | T(0.57) |
| Â | Â | Â | rs14075352 | 14:7019820 | Intronic (C/G) | C(0.90) |