Relationship between climate and genetic variation around genes ADRA2A and ADRA2C . Interpolated worldwide distributions of Summer Precipitation and Winter Temperature are presented in panels A and B respectively. Our two top hits, ADRA2A and ADRA2C were identified as loci in which two or more populations exhibit unusually strong or weak genetic differentiation relative to that expect based on genome-wide FST. To capture this, for each population we calculated the slope of the relationship between FST at the locus of interest and geographic separation after correcting for genomewide FST. Panels C and D present heat maps of these slopes for ADRA2A and ADRA2C respectively. As seen, the climate heat maps are a close match for the inverse of the genetic differentiation heat maps.