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Figure 4 | BMC Genetics

Figure 4

From: An EM algorithm based on an internal list for estimating haplotype distributions of rare variants from pooled genotype data

Figure 4

Expected sum of squared errors of the EM-ATCDL estimator with fixed threshold (32 loci case). Expected sum of squared errors of the EM-ATCDL estimator for various choices of the threshold based on 100 simulations of n=200 pools of (a) k=2 and (b) k=4 individuals each when the true haplotype distribution over 32 loci is as given in Table 4; optimal threshold: the threshold obtained by minimizing the averaged sum of squared errors; average adaptive threshold: adaptively chosen thresholds obtained by minimizing the distance between f ̂ (0) and f(0) over the grid 0.0001 to 0.002 in steps of 0.0001.

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