Association analysis of complex diseases using triads, parent-child dyads and singleton monads

Fan, Ruzong; Lee, Annie; Lu, Zhaohui; Liu, Aiyi; Troendle, James F; Mills, James L

doi:10.1186/1471-2156-14-78

BMC Genomic Data

Table 3 Power performance of the proposed tests at 0.05 nominal significance level using the parameter in Table three, Troendle et al. [19] and n = 500

From: Association analysis of complex diseases using triads, parent-child dyads and singleton monads

Sample size			p	Disease model		Model					TDT	z _{c o m}
s	n	m		Model	(ψ₁,ψ₂)	Dom	Rec	Mult	Unr	Add
				Dom	(1.5, 1.5)	0.91984	0.05494	0.59684	0.86250	0.67998		0.38389
		125	0.5	Rec	(1.0, 1.45)	0.04830	0.91488	0.68434	0.85930	0.61349		0.46383
		125	0.5	Mult	(1.3, 1.69)	0.54475	0.63588	0.88638	0.81607	0.88395		0.67525
0	500			Unr	(0.82, 1.22)	0.40678	0.94369	0.28652	0.95067	0.19831		0.19157
0	500			Dom	(1.5, 1.5)	0.86469	0.05501 ^∗	0.53494	0.78362	0.61161	0.53133
		0	0.5	Rec	(1.0, 1.45)	0.04868 ^∗	0.86048	0.62189	0.78284	0.54995	0.61559
		0	0.5	Mult	(1.3, 1.69)	0.50217 ^∗	0.58591 ^∗	0.83504	0.74791	0.82951	0.83316
				Unr	(0.82, 1.22)	0.30751	0.88989	0.25717	0.89710	0.18219	0.25521
				Dom	(1.5, 1.5)	0.93417	0.05975	0.61089	0.88359	0.69680
		125	0.5	Rec	(1.0, 1.45)	0.04970	0.93022	0.70132	0.87754	0.62959
		125	0.5	Mult	(1.3, 1.69)	0.55266	0.64473	0.89571	0.83059	0.89378
50	500			Unr	(0.82, 1.22)	0.46190	0.95843	0.29617	0.96292	0.20571
50	500			Dom	(1.5, 1.5)	0.88543	0.05450	0.55038	0.81938	0.63176
		0	0.5	Rec	(1.0, 1.45)	0.04813	0.88221	0.63748	0.81229	0.56987
		0	0.5	Mult	(1.3, 1.69)	0.50941	0.59514	0.85057	0.77031	0.84857
				Unr	(0.82, 1.22)	0.35793	0.91611	0.26407	0.92113	0.18285
				Dom	(1.45, 1.45)	0.91663	0.05581	0.82275	0.85564	0.85475		0.59268
		125	0.2	Rec	(1.0, 2.0)	0.04455	0.94790	0.44326	0.90851	0.34805		0.28523
		125	0.2	Mult	(1.35, 1.82)	0.74330	0.29700	0.86030	0.77766	0.85735		0.63475
0	500			Unr	(0.73, 1.37)	0.75736	0.83819	0.16262	0.95415	0.09838		0.11611
0	500			Dom	(1.45, 1.45)	0.86430	0.05206 ^∗	0.76184	0.78832	0.79620	0.76041
		0	0.2	Rec	(1.0, 2.0)	0.04254 ^∗	0.90108	0.39325	0.84045	0.30808	0.38860
		0	0.2	Mult	(1.35, 1.82)	0.67838 ^∗	0.27300 ^∗	0.79869	0.70763	0.79626	0.79935
				Unr	(0.73, 1.37)	0.65414	0.73828	0.14995	0.90150	0.09179	0.14809
				Dom	(1.45, 1.45)	0.92776	0.05929	0.83556	0.87192	0.86570
		125	0.2	Rec	(1.0, 2.0)	0.04580	0.95984	0.45325	0.92594	0.35732
		125	0.2	Mult	(1.35, 1.82)	0.75081	0.29775	0.86878	0.79374	0.86823
50	500			Unr	(0.73, 1.37)	0.79247	0.87274	0.17039	0.96622	0.09941
50	500			Dom	(1.45, 1.45)	0.88237	0.05344	0.78154	0.81038	0.81656
		0	0.2	Rec	(1.0, 2.0)	0.04352	0.92016	0.40450	0.87014	0.31454
		0	0.2	Mult	(1.35, 1.82)	0.69361	0.27258	0.81773	0.72982	0.81359
				Unr	(0.73, 1.37)	0.69897	0.78788	0.15242	0.92672	0.09045
				Dom	(1.45, 1.45)	0.54540	0.01899	0.51668	0.41742	0.53330		0.32711
		125	0.05	Rec	(1.0, 2.0)	0.04787	0.19369	0.06095	0.15167	0.04953		0.05595
		125	0.05	Mult	(1.35, 1.82)	0.37363	0.06127	0.39755	0.30298	0.39613		0.25117
0	500			Unr	(0.73, 1.37)	0.32954	0.14447	0.25594	0.32487	0.23685		0.16860
0	500			Dom	(1.45, 1.45)	0.47895	0.02234	0.45528	0.35409	0.46737	0.45051
		0	0.05	Rec	(1.0, 2.0)	0.04759	0.17392	0.06026	0.13605	0.04958	0.05914
		0	0.05	Mult	(1.35, 1.82)	0.32514	0.06317	0.34478	0.26105	0.34585	0.34717
				Unr	(0.73, 1.37)	0.28430	0.12649	0.22702	0.27964	0.20895	0.22606
				Dom	(1.45, 1.45)	0.55918	0.01811	0.53173	0.43260	0.54426
		125	0.05	Rec	(1.0, 2.0)	0.04848	0.20376	0.06147	0.15963	0.04985
		125	0.05	Mult	(1.35, 1.82)	0.38246	0.06150	0.41190	0.31308	0.40672
50	500			Unr	(0.73, 1.37)	0.34311	0.14948	0.27061	0.34266	0.22740
50	500			Dom	(1.45, 1.45)	0.49431	0.02036	0.46935	0.36889	0.48220
		0	0.05	Rec	(1.0, 2.0)	0.04777	0.17937	0.06071	0.14178	0.05204
		0	0.05	Mult	(1.35, 1.82)	0.33955	0.06127	0.36054	0.26850	0.35641
				Unr	(0.73, 1.37)	0.29572	0.13457	0.23367	0.29240	0.20284

∗ indicates entry that is slightly lower than the corresponding entry of Table three, Troendle et al. [19].

Back to article page

ISSN: 2730-6844

Contact us

General enquiries: journalsubmissions@springernature.com