Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa

BMC Genomic Data

Table 6 Age estimates of clinically relevant CYP3A5 variants

*CYP3A5*variant	Location on chromosome 7	Location in gene	Allele dated	Number of chromosomes	Average squared distance (ASD)	Time to most recent common ancestor		95% confidence intervals of allele age estimate based on a star phylogeny
						Estimate of allele age		Lower		Upper
						Generations	Years	Generations	Years	Generations	Years
**CYP3A53***	99270539	Intron 3	G	134	1.0746	2388	76,416	1797	57,504	3211	102,752
**CYP3A56***	99262835	Exon 7	A	18	3.0714	6825	218,400	3086	98.752	11975	383,200
rs15524	99245914	3´ UTR	T	324	1.8426	4095	131,040	3157	101,024	5413	173,216

Allele ages were estimated using a mutation rate of 0.00045 and a generation time of 32 years. The confidence intervals for the estimated age of the CYP3A5*6 are large; most likely a reflection of the small sample size. UTR is the Untranslated Region.

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