(A) Cerebellar folia of four-week old Beagle puppy with NCCD. Loss of occasional Purkinje cells (grey arrows). The black arrow identifies a degenerating Purkinje cell with hypereosinophilic cytoplasm and a condensed nucleus. 100x magnification. (B). Cerebellar folia of eight-week old full-sibling Beagle puppy with NCCD. Marked loss of Purkinje cells (grey arrows). Associated granular cell layer depletion secondary to Purkinje cell loss (white double headed arrows). 100x magnification.