Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5

Table 2 Summary of results across cohorts for four candidate genes identified through parallel analysis.

Gene	SNP	Quantitative Results			Qualitative Results
		(LDL Cholesterol Traits)			(CAD, Atherosclerosis)
		LDL-GENECARD	LDLP-CATHGEN	Fisher's Combined	GENECARD	CATHGEN	GENECARD Probands-CATHGEN Controls	Aortas	Linkage (LOD)
*PPP2R2B*	rs10037715	0.05	0.77	0.15	0.82	0.31	0.25	0.68	-17.8
	rs2125443	0.38	0.001	0.01	0.71	0.31	0.84	0.13	-14.4
	rs7736604	0.92	0.01	0.06	0.0003	0.22	0.45	0.02	-13.2
	rs160974	0.92	0.62	0.62	0.47	0.004	0.50	0.65	-18.0
	rs1383169	0.81	0.11	0.31	0.39	0.01	0.01	0.49	-9.3
	rs1383167	0.99	0.28	0.63	0.45	0.08	0.92	0.02	-14.2
*EBF1*	rs17717527	0.01	0.73	0.05	0.40	0.55	0.13	0.31	-19.5
	rs6865969	0.84	0.01	0.05	0.40	0.01	0.13	0.02	-20.0
	rs4704963	0.78	0.24	0.51	0.03	0.67	0.38	0.46	-6.4
	rs17712788	0.08	0.90	0.90	0.85	0.33	0.01	0.16	-8.3
*SPOCK1*	rs10054991	0.05	0.84	0.17	0.72	0.79	0.14	0.33	-14.8
	rs17600115	0.33	0.003	0.001	0.85	0.27	0.43	0.05	-5.7
	rs17170899	0.71	0.98	0.95	0.004	0.63	0.82	0.86	-1.6
	rs6872714	0.19	0.80	0.44	0.91	0.02	0.64	0.04	-16.8
	rs6884385	0.16	0.17	0.13	0.86	0.06	0.02	0.24	-16.0
	rs2043478	0.88	0.77	0.94	0.49	0.33	0.23	0.01	-17.3
	rs1919515	0.80	0.59	0.82	0.42	0.74	0.05	0.36	1.8
*PRELID2*	rs10074645	0.0002	0.71	0.001	0.93	0.67	0.19	0.66	-2.7
	rs11950106	0.73	0.04	0.12	0.56	0.09	0.30	0.73	-13.7
	rs7713855	0.93	0.54	0.85	0.77	0.003	0.13	0.33	-16.2
	rs13179436	0.65	0.77	0.85	0.52	0.005	0.03	0.26	-16.0
	rs443033	0.50	0.90	0.81	0.48	0.05	0.14	0.04	-10.1
	rs7736046	0.98	0.80	0.98	0.86	0.03	0.81	0.19	2.1

P-values for the most significant results for SNPs for each analysis for the four top candidate genes (PPP2R2B, EBF1, SPOCK1, and PRELID2) are presented. The most significant result for each gene and analysis is in bold.

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