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Table 2 Association of the SNP in intron 5 of the ACSL1 gene (c.481-233A>G) with variation in intramuscular fatty acid composition and fat content

From: Association of an ACSL1 gene variant with polyunsaturated fatty acids in bovine skeletal muscle

  Model without IMF as covariate Model with IMF as covariate
Trait* LRT p-value Effect allele A SE Effect allele G SE Var [%]** LRT p-value Effect allele A SE Effect allele G SE
Total FA [mg]*& 6.2 0.0130 3.70 0.07 3.88 0.07   3.8 0.0507     
MUFA [mg]*& 5.9 0.0154 3.29 0.08 3.48 0.09   2.9 0.0874     
n-3 FA [%]*# 9.7 0.0018a 0.16 0.05 0.01 0.06 11.4 5.8 0.0159 0.42 0.04 0.36 0.04
PUFA [%]*# 7.1 0.0079b 1.12 0.05 0.98 0.06 3.5 3.9 0.0477     
n-3 LC PUFA [%]# 6.7 0.0099b 0.24 0.03 0.16 0.04 3.4 3.5 0.0628     
C18:1trans-11 [mg]*& 10.5 0.0012a 1.31 0.10 1.63 0.12 6.5 8.1 0.0045a 0.86 0.09 1.07 0.10
C22:5n-3 [%]# 7.2 0.0071 b 0.16 0.02 0.11 0.03 3.6 5.9 0.0150 0.27 0.02 0.23 0.02
PUFA/SFA* 7.3 0.0069b -0.79 0.06 -0.94 0.07 3.6 4.2 0.0407     
P/S* 6.7 0.0099b -1.02 0.05 -1.15 0.06 3.2 3.2 0.0758     
LA/ALA* 4.9 0.0265 1.03 0.03 0.97 0.03   1.9 0.1720     
IMF [%] 3.1 0.0776 1.11 0.18 1.42 0.21 1.7       
  1. *Trait data log-transformed, &absolute content of fatty acids (mg/100 g of skeletal muscle), #relative content of fatty acids (percentage of the respective fatty acid fraction relative to total fatty acid amount)
  2. LTR: likelihood ratio test, p: significancy of allelic effects, Var: variance explained, SE: standard error, aq-value <0.05, bq-value <0.1, **% variance in the model calculated as the relative reduction of the residual variance due to including the SNP in the model [47].
  3. Allelic effects of the ACSL1 SNP (c.481-233A>G) on different FA fractions: n-3 fatty acids (n-3 FA = C18:3n-3 + C18:4n-3 + C20:5n-3 + C22:5n-3 + C22:6n-3), poly-unsaturated fatty acids (PUFA = n-3 FA + n-6 FA [C18:2n-6 + C18:3n-6 + C20:2n-6 + C20:3n-6 + C20:4n-6 + C22:2n-6 + C22:4n-6]), n-3 long-chain PUFA (n-3 LC-PUFA = C20:3n-3 + C22:6n-3 + C22:5n-3 + C20:5n-3), total FA, mono-unsaturated fatty acids (MUFA), docosapentaenoic fatty acid (DPA, C22:5n-3), trans vaccenic acid (TVA, C18:1trans-11) and the ratios: PUFA/SFA (saturated fatty acids = C12:0 + C14:0 + C16:0 + C17:0 + C18:0 + C20:0 + C24:0), P/S (C18:2 n-6 + C18:3 n-3/C14:0 + C16:0 + C18:0), LA/ALA (C18:2 n-6/C18:3 n-3), and the intramuscular fat content (IMF).