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Table 3 Genotype-phenotype association analysis for muscular subsystem gene polymorphisms and baseline aerobic power and changes after training in the CAREGENE study

From: A genetic predisposition score for muscular endophenotypes predicts the increase in aerobic power after training: the CAREGENE study

Gene Polymorphism Allele Frequency VO2pre p-value VO2change p-value VO2change p-value
    N (%) (ml/min)a   (ml/min)b   (%) b  
AMPD1 C34T/rs17602729 CC 652 (71) 1711 ± 15 p = 0.40 396 ± 10 p = 0.11 24.8 ± 0.6 p = 0.04
   CT + TT 263 (29) 1734 ± 23   367 ± 16   22.4 ± 0.99  
CNTF G-6A/rs1800169 GG 664 (73) 1724 ± 15 p = 0.43 369 ± 9 p = 0.001 23.1 ± 0.6 p = 0.002
   GA 226 (25) 1701 ± 25   416 ± 16   25.1 ± 1.0  
   AA 21 (2) 1801 ± 81   519 ± 52   33.9 ± 3.3  
GR R23K/rs6190 GG 857 (94) 1715 ± 13 p = 0.08 383 ± 9 p = 0.02 23.8 ± 0.6 p = 0.04
   GA + AA 55 (6) 1805 ± 50   464 ± 34*   28.5 ± 2.2*  
  1. AMPD1, Adenosine monophosphate deaminase; CNTF, Ciliary neurotrophic factor; GR, Glucocorticoid receptor
  2. a. Mean ± SE, corrected for gender, age, height and weight;
  3. b. Mean ± SE, corrected for gender, age, height, weight and baseline peakVO2