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Table 3 Relationship between IL12 B 3' UTR genotypes and susceptibility to SMA

From: Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria

IL-12B 3' UTR Genotype OR 95% CI P OR 95% CI P
  SMA (Hb<5.0 g/dL) SMA (Hb<6.0 g/dL)
AA reference    reference   
AC 1.268 0.799-2.011 0.314 1.410 0.953-2.098 0.086
CC 1.512 0.870-2.629 0.142 1.674 1.006-2.673 0.047
CC vs. AC + AA 1.335 0.816-2.185 0.249 1.370 0.880-2.133 0.826
AA vs. AC+CC 1.346 0.881-2.058 0.170 1.479 1.031-2.123 0.034
  1. Parasitaemic children (n = 544) were categorized according to the WHO SMA definition [i.e., Hb<5.0 g/dL, with any density parasitaemia [26]] and the age- and geographically-appropriate definition of SMA [(Hb<6.0 g/dL, with any density parasitaemia [4]]. Odds Ratio (OR) and 95% confidence interval (CI) were determined using multivariate logistic regression controlling for age, gender, HIV-1, bacteremia, and sickle-cell trait (HbAS) status.