Table 3 Comparative positional analysis of identified QTL with serum lipid QTL in humans and mice and the putative candidate genes located on the QTL regions

1

CT*

80

1q1.3 - 1.4

18q21

15q21-22

CT

18q21 [51]

LIPC[52], LIPG[53], ACAA2[54], STARD6[55]

(B6 × C3H) F₂

(B6 × DBA/2) F₂

(B6 × CAST/2) F₂

(B6 × C3H) F₂

18-40cM

18-46cM

18-47cM

18-48cM

1

HDL/LDL**

87

1q1.5-1.6

HDL

15q21 [56], 15q22 [57]

(B6 × 129) F₂

2-90 cM

1

LDL***

82

1q1.3 - 1.4

LDL-ApoB1

18q21.32 [58]

2

TG

205

2q2.8-2.9

5q23-31

TG

5 q21.3 -q32 [59]

STARD4[60]

2

HDL*#

118

2p1.2- 2q1.2

11q13

HDL

11q12-13 [31]

CILP, PBX4

(MRL × SJL) F₂

(B6 × C3H) F₂

7-10 cM

7-19 cM

3

HDL*

0

3p1.5-p1.4

7q11

HDL

TC

7q11.23 [61]

7q11.23 [62]

FABP1

(NZB × SM) F₂

NZO × (SJL × NZO)

(B6 × CAST) F₂

5-61.cM

5-69cM

5-72 CM

4

HDL/LDL*

58

4q1.4-1.5

1q22-25

HDL

1q21-23 [63]

1q23-25 [64];

1q24 [65], 1q25 [66]

CYP7A1[67, 68];

FABP5[69]

(B6 × NZB11) F₂

1-91 CM

6

CT*

99

6q2.3 - 2.4

1p36.3-36.1

LDL

1q36.31 [63]

1q36.13 [70]

NR1H2

WWOX [71] LDLRAP1

6

TG*

66

6q1.1 - 2.1

19q13

LDL,

TG

19 q12 39 cM [72]

19q13.31 [51], [73]

APOE [74]; ANGPTL3

7

CT, LDL*

70

7q1.4-71.5

15q24-28

LDL

15q26.1 [51]

STARD5

11

TG*^#

28

11p1.1 -1.2

13q12 -24

TG and HDL

13q13 [75]

12

CT**

36

12p1.3-q1.2

17q21-25

CT/HDL

17q24 [76]

WIPI1,

12

LDL*

38

LDL

17q24.2 [65]; 17q25.3 [77]

THRA PEMT

13

LDL*

97

13q3.3 -3.5

3p31-21

LDL

3p25 [72]

PCYT1A[78]; B4GALT4[79]

(C56BL/6JxDBA/2J)

3-27cM [80]

16

HDL*

81

16q1.4-2.1

5p14 -12

HDL

5p13.3 [81]

5p15.13 [82]

(PERAxDBA/2) F₂

(PERAxI) F₂

11-28 cM

11-28 cM

16

HDL/LDL*

47

16q1.3-1.4

5p14 -12

LDL

5p15.33 [64]

17

TG*^#

72

17q2.2-2.3

13q13

TG and HDL

13q13 [75]

ACSS, PLTP