The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans

BMC Genomic Data

Table 1 Allelic Frequencies FADS Gene Cluster Variants Differ by Race.

SNP		Allele associated with increased LC-PUFAS	GeneSTAR^a		DHS^b		HapMap^c
[ancestral/derived allele]^d	Position		African American	European American	African American	European American	CEU	ASW	YRI
rs174537 [T/G]	61309256	G	0.91	0.67	0.89	0.65	0.66	0.92	0.99
rs102275 [A/G]	61314379	A	0.37	0.67	0.33	0.64	0.65	0.39	0.31
rs174546 [T/C]	61326406	C	0.92	0.67	0.91	0.65	0.66	0.92	0.99
rs174556 [C/T]	61337211	C	0.92	0.71	0.91	0.68	0.7	0.93	0.99
rs1535 [G/A]	61354548	A	0.86	0.67	0.83	0.64	0.66	0.88	0.88
rs174576 [A/C]	61360086	C	0.74	0.66	0.7	0.64	0.66	0.71	0.72
rs174579 [C/T]	61362189	C	0.95	0.79	0.92	0.79	0.77	0.95	0.99

Frequencies of the allelic variant associated with higher levels of LC-PUFAs at seven SNPs mapping to the FADS gene cluster in the family-based GeneSTAR study, subjects from the DHS study, and the publicly availably HapMap project, illustrating higher frequencies in individuals of African ancestry.
^aAllele frequency estimates were obtained from in a defined set of all founders from the GeneSTAR families (339 African American founders and 484 European American founders).
^bFrequency based on 33 independent African American and 89 independent European American subjects from the DHS.
^cData on the Utah residents with Northern and Western European ancestry from the CEPH collection (CEU), Yoruban in Ibadan, Nigeria (YRI) and African ancestry in Southwestern USA (ASW) from the publicly available International HapMap Project (www.hapmap.org).
^dDefinition of ancestral/derived allele based on dbSNP definitions (http://www.ncbi.nlm.nih.gov/projects/SNP/).

ISSN: 2730-6844