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Table 1 Parameters for Simulation under Alternative Hypothesis

From: A powerful hybrid approach to select top single-nucleotide polymorphisms for genome-wide association study

  Disease Locus 1 Marker 1 Disease Locus 2 Marker 2
  (D1) (M1) (D2) (M2)
OR 1.8   1.5  
MAF 10% 10% 40% 40%
  1. OR = odds ratio, MAF = minor allele frequency, LD = linkage disequilibrium.
  2. The LD between the disease loci and the corresponding marker loci is 0.8, and the two disease loci are in linkage equilibrium.