Table 1 Type I error rates of GMS and GME based on 10,000 replicates without confounding (Scenario 1) and in the presence of confounding factors (Scenarios 2-8), with the significance level 0.05 using r l cases and s l controls; p l is the risk allele frequency and k l is the prevalence, l = 1,2.
From: Robust tests for matched case-control genetic association studies
Scenario | r 1 | r 2 | s 1 | s 2 | p 1 | p 2 | k 1 | k 2 | GMS | GME |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 250 | 250 | 250 | 250 | 0.3 | 0.3 | 0.05 | 0.05 | 0.0510 | 0.0502 |
2 | 250 | 250 | 250 | 250 | 0.05 | 0.5 | 0.01 | 0.1 | 0.0199 | 0.0141 |
3 | 250 | 250 | 250 | 250 | 0.1 | 0.5 | 0.01 | 0.1 | 0.0190 | 0.0167 |
4 | 250 | 250 | 250 | 250 | 0.2 | 0.4 | 0.03 | 0.07 | 0.0391 | 0.0384 |
5 | 300 | 200 | 200 | 300 | 0.2 | 0.4 | 0.03 | 0.07 | 0.3923 | 0.4403 |
6 | 325 | 175 | 175 | 325 | 0.2 | 0.4 | 0.03 | 0.07 | 0.7337 | 0.7880 |
7 | 350 | 150 | 150 | 350 | 0.2 | 0.4 | 0.03 | 0.07 | 0.9077 | 0.9567 |
8 | 375 | 125 | 125 | 375 | 0.2 | 0.4 | 0.03 | 0.07 | 0.9625 | 0.9954 |