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Table 1 SNP and SNP-set associations with measures of mathematics at age 10.

From: Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities

    Web Measures Teacher-rated Measures
  Mathematics composite at 10 Web total Understanding number Non-numerical processes Computation and knowledge Teacher total Using and applying Number and algebra Shapes, space & measures
  Cor N Cor N Cor N Cor N Cor N Cor N Cor N Cor N Cor N
rs11225308 0.074** 2184 0.077** 1723 0.064** 1723 0.072** 1723 0.066** 1723 0.055** 1795 0.059** 1811 0.043* 1815 0.048* 1800
rs363449 0.069** 2182 0.070** 1703 0.057** 1703 0.041* 1703 0.075** 1703 0.067** 1802 0.070** 1820 0.064** 1823 0.063** 1807
rs17278234 0.067** 2188 0.050* 1708 0.059** 1708 0.038* 1708 0.033 1708 0.062** 1805 0.052* 1823 0.065** 1826 0.064** 1810
10-SNP set 0.167** 1888 0.145** 1486 0.151** 1486 0.107** 1486 0.119** 1486 0.145** 1551 0.132** 1567 0.146** 1571 0.141** 1556
43-SNP set 0.164** 1893 0.149** 1490 0.144** 1490 0.113** 1490 0.127** 1490 0.145** 1553 0.134** 1569 0.145** 1573 0.140** 1558
r p NA NA 0.911** 1854 0.822** 1845 0.714** 1854 0.822** 1854 0.915** 1933 0.872** 1967 0.880** 1970 0.876** 1957
  1. Results of the tests of association of components of the mathematics composite at age 10 with rs11225308, rs363449, rs17278234, and the 10- and 43-SNP sets previously associated with the mathematics composite score. Associations are presented as correlations between the quantitative traits and additive genotypic values (as 0, 1, and 2 'increasing' alleles) for SNPs and additive SNP scores for SNP sets. Mathematics composite at 10 = the originally associated measure of mathematics at age 10; Web total = total web-test score at age 10; Understanding Number, Non-numerical Processes and Computation and Knowledge = three components of the web-test; Teacher total = teacher rating of mathematics at age 10; Using and Applying, Number and Algebra and Shapes, space and measures = three components of the teacher rating; Cor = Pearson product-moment correlations (p-values included in italics); N = size of sample analysed; r p = phenotypic correlation with mathematic composite score at age 10. One-tailed p-values were generated for all SNP-associations. * = nominally significant associations (p < 0.05). ** = associations withstanding Bonferroni testing for the five (three individual SNP and two SNP-set) association tests conducted simultaneously for each measure (p < 0.01).