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Table 4 Comparison of the risk of SCC of the oesophagus associated with different GST genotypes

From: The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer

Genotypes Patients N(%) Controls N(%) OR (95%CI) p-value Patients N(%) Controls N(%) OR (95%CI) p-value
  GSTM1*0 GSTM1*1
GSTM1*1 98 (87) 65 (64) 1.00 108 (85) 135 (76) 1.00
GSTM1*0 15 (13) 37 (36) 0.27 (0.12-0.62) 0.002 19 (15) 43 (24) 0.36 (0.17-0.76) 0.008
GSTP1 313A/A 49 (43) 38 (37) 1.00 43 (34) 69 (39) 1.00
GSTP1 313 A/G 49 (44) 50 (49) 0.51 (0.25-1.05) 0.069 62 (49) 84 (47) 1.28 (0.69-3.37) 0.434
GSTP1 313G/G 15 (13) 14 (14) 0.42 (0.13-1.33) 0.139 22 (17) 25 (14) 2.36 (1.04-5.37) 0.041
GSTP1 341 C/C 70 (62) 94 (92) 1.00 80 (63) 158 (89) 1.00
GSTP1-341C/T + GSTP1-341T/T 43 (38) 8 (8) 14.9 (5.64-39.4) 0.001 47 (37) 20 (11) 3.76 (1.82-7.77) 0.001
  GSTM1*0 GSTM1*1
GSTT1*1 19 (56) 43 (54) 1.00 108 (52) 135 (68) 1.00
GSTT1*0 15 (44) 37 (46) 0.73 (0.25-2.10) 0.559 98 (48) 65 (32) 1.55 (093-2.58) 0.093
GSTP1 313A/A 13 (38) 32 (40) 1.00 79 (38) 75 (37) 1.00
GSTP1 313 A/G 15 (44) 39 (49) 1.63 (0.52-5.12) 0.40 96 (47) 95 (48) 0.80 (0.47-1.36) 0.417
GSTP1 313G/G 6 (18) 9 (11) 2.78 (0.59-13.0) 0.193 31 (15) 30 (15) 1.04 (0.50-2.19) 0.914
GSTP1 341 C/C 22 (65) 73 (91) 1.00 128 (62) 179 (90) 1.00
GSTP1-341C/T + GSTP1-341T/T 12 (35) 7 (9) 6.06 (1.79-20.5) 0.004 78 (38) 21 (10) 6.31 (3.26-12.2) 0.001
  1. OR, odds ratios adjusted for age, sex, race, tobacco smoking, alcohol consumption and use of charcoal or wood for cooking. *1 signifies carrier of gene, *0 signifies homozygous gene deletion.