Table 4 Comparison of the risk of SCC of the oesophagus associated with different GST genotypes
From: The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer
Genotypes | Patients N(%) | Controls N(%) | OR (95%CI) p-value | Patients N(%) | Controls N(%) | OR (95%CI) p-value |
|---|---|---|---|---|---|---|
| Â | GSTM1*0 | GSTM1*1 | ||||
GSTM1*1 | 98 (87) | 65 (64) | 1.00 | 108 (85) | 135 (76) | 1.00 |
GSTM1*0 | 15 (13) | 37 (36) | 0.27 (0.12-0.62) 0.002 | 19 (15) | 43 (24) | 0.36 (0.17-0.76) 0.008 |
GSTP1 313A/A | 49 (43) | 38 (37) | 1.00 | 43 (34) | 69 (39) | 1.00 |
GSTP1 313 A/G | 49 (44) | 50 (49) | 0.51 (0.25-1.05) 0.069 | 62 (49) | 84 (47) | 1.28 (0.69-3.37) 0.434 |
GSTP1 313G/G | 15 (13) | 14 (14) | 0.42 (0.13-1.33) 0.139 | 22 (17) | 25 (14) | 2.36 (1.04-5.37) 0.041 |
GSTP1 341 C/C | 70 (62) | 94 (92) | 1.00 | 80 (63) | 158 (89) | 1.00 |
GSTP1-341C/T + GSTP1-341T/T | 43 (38) | 8 (8) | 14.9 (5.64-39.4) 0.001 | 47 (37) | 20 (11) | 3.76 (1.82-7.77) 0.001 |
| Â | GSTM1*0 | GSTM1*1 | ||||
GSTT1*1 | 19 (56) | 43 (54) | 1.00 | 108 (52) | 135 (68) | 1.00 |
GSTT1*0 | 15 (44) | 37 (46) | 0.73 (0.25-2.10) 0.559 | 98 (48) | 65 (32) | 1.55 (093-2.58) 0.093 |
GSTP1 313A/A | 13 (38) | 32 (40) | 1.00 | 79 (38) | 75 (37) | 1.00 |
GSTP1 313 A/G | 15 (44) | 39 (49) | 1.63 (0.52-5.12) 0.40 | 96 (47) | 95 (48) | 0.80 (0.47-1.36) 0.417 |
GSTP1 313G/G | 6 (18) | 9 (11) | 2.78 (0.59-13.0) 0.193 | 31 (15) | 30 (15) | 1.04 (0.50-2.19) 0.914 |
GSTP1 341 C/C | 22 (65) | 73 (91) | 1.00 | 128 (62) | 179 (90) | 1.00 |
GSTP1-341C/T + GSTP1-341T/T | 12 (35) | 7 (9) | 6.06 (1.79-20.5) 0.004 | 78 (38) | 21 (10) | 6.31 (3.26-12.2) 0.001 |