Skip to main content

Table 2 Interactions between GST genotypes, alcohol consumption, tobacco smoking and fuel source among oesophageal cancer patients and controls

From: The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer

Genotypes Patients N(%) Controls N(%) OR (95%CI) p-value Patients N(%) Controls N (%) OR (95%CI) p-value
  Tobacco smokers a Non smokers a
GSTT1*1 100 (56) 112 (61) 1.00 27 (43) 66 (69) 1.00
GSTT1*0 77 (44) 73 (39) 1.01 (0.62-1.66) 0.951 36 (57) 29 (31) 2.92(1.04-8.16) 0.042
GSTM1*1 151 (85) 125 (68) 1.00 55 (87) 75 (79 1.00
GSTM1*0 125 (15) 60 (32) 0.30 (0.16-0.56) 0.001 8 (13) 20 (21) 0.46 (0.12-1.81) 0.269
GSTP1 313A/A 71 (40) 77 (42) 1.00 21 (33) 30 (32) 1.00
GSTP1 313 A/G 78 (44) 86 (46) 0.96 (0.58-1.61) 0.898 33 (52) 48 (50) 0.53 (0.18-1.51) 0.233
GSTP1 313G/G 28 (16) 22 (12) 1.54 (0.74-3.21) 0.250 9 (14) 17 (18) 0.44 (0.10-1.93) 0.278
GSTP1 341 C/C 106 (60) 166 (90) 1.00 44 (70) 86 (91) 1.00
GSTP1-341C/T + GSTP1-341T/T 71 (40) 19 (10) 7.51 (3.82-14.7) 0.001 19 (30) 9 (9) 5.31 (2.58-27.6) 0.001
  Alcohol consumers b Non consumers b
GSTT1*1 89 (54) 101 (60) 1.00 38 (51) 77 (68) 1.00
GSTT1*0 76 (46) 66 (40) 1.03 (0.60-1.77) 0.911 37 (49) 36 (32) 1.66 (0.77-3.59) 0.197
GSTM1*1 143 (87) 123 (74) 1.00 63 (84) 77 (68) 1.00
GSTM1*0 22 (13) 44 (26) 0.33 (0.16-0.66) 0.002 12 (16) 36 (32) 0.27 (0.10-0.74) 0.011
GSTP1 313A/A 63 (38) 74 (44) 1.00 29 (39) 33 (29) 1.00
GSTP1 313 A/G 80 (48) 75 (45) 1.22 (0.70-2.13) 0.474 31 (41) 58 (52) 0.41 (0.17-0.96) 0.039
GSTP1 313G/G 22 (13) 18 (11) 1.69 (0.72-3.95) 0.226 15 (20) 22 (19) 0.64 (0.24-1.76) 0.394
GSTP1 341 C/C 105 (64) 148 (89) 1.00 45 (60) 104 (92) 1.00
GSTP1-341C/T + GSTP1-341T/T 60 (36) 19 (11) 15.3 (1.81-12.9) 0.012 30 (40) 9 (8) 10.9 (4.09-28.9) 0.001
  Wood or charcoal users c Non users c
GSTT1*1 54 (61) 25(58) 1.00 52 (60) 153 (65) 1.00
GSTT1*0 34 (39) 18 (42) 0.77 (0.35-1.68) 0.510 35 (40) 84 (35) 1.67 (0.94-2.93) 0.080
GSTM1*1 72 (82) 27 (63) 1.00 77 (89) 173 (73) 1.00
GSTM1*0 16 (18) 16 (37) 0.41 (0.17-0.96) 0.041 10 (11) 64 (27) 0.26 (0.12-0.56) 0.001
GSTP1 313A/A 38 (43) 17 (40) 1.00 34 (39) 90 (38) 1.00
GSTP1 313 A/G 34 (39) 23 (53) 0.71 (0.30-1.69) 0.441 41 (47) 110 (46) 0.97 (0.55-1.73) 0.922
GSTP1 313G/G 16 (18) 3 (7) 3.28 (0.79-13.7) 0.103 12 (14) 37 (16) 1.11 (0.48-2.53) 0.809
GSTP1 341 C/C 42 (48) 40 (93) 1.00 57 (66) 212 (89) 1.00
GSTP1-341C/T + GSTP1-341T/T 46 (52) 3 (7) 12.1 (3.26-49.0) 0.001 30 (34) 25 (11) 4.93 (2.47-9.84) 0.001
  1. *1 signifies carrier of gene, *0 signifies homozygous gene deletion. Odds ratios adjusted for aalcohol consumption, race, sex, age, wood or charcoal use; btobacco smoking , race, sex, age, wood or charcoal use; calcohol consumption, race, sex, age, tobacco smoking