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Table 3 Estimates of mutation age for BRCA2 6174delT.

From: How old is this mutation? - a study of three Ashkenazi Jewish founder mutations

Method Estimated mutation age (generations) Estimated mutation age assuming growth rate r = 1.125 Estimated mutation age assuming growth rate r = 1.21 95% credible interval (DMLE) or 95% confidence interval (Goldgar)
Neuhausen et al. (1998) [13] 29    1-LOD interval [22, 38]
Single marker results, median of 28 markers1 25.17 38.94 36.02  
DMLE, 6 markers N/A 81.27 51.77 r = 1.125: [62.13, 102.34]
r = 1.21: [40.53, 64.78]
DMLE, 10 markers N/A 88.56 58.65 r = 1.125:[67.19, 113.57]
r = 1.21:[45.48, 74.46]
DMLE, 14 markers N/A 90.50 60.53 r = 1.125:[71.37, 114.24]
r = 1.21:[48.49, 75.23]
Goldgar method2, 6 markers 9 33.31 25.42 r = 1.0: [≤ 1, 124]
r = 1.125: [≤ 24.31,148.31]
r = 1.21 [≤ 17.42,141.42]
Goldgar method2, 10 markers 17 41.31 34.42 r = 1.0: [≤ 1, 70]
r = 1.125: [≤ 24.31, 94.31]
r = 1.25: [≤ 17.42, 87.42]
Goldgar method2, 14 markers 15 39.31 32.42 r = 1.0: [≤ 1, 42]
r = 1.125: [≤ 24.31, 66.31]
r = 1.21: ≤ 17.42, 59.42]
  1. 1The single marker result shows the median estimate of mutation age across 28 out of 48 markers near the mutation for which a single marker estimate was possible (see Additional file 3). The correction for growth was based on the median Labuda correction across 28 markers for which a single marker estimate of mutation age was possible.
  2. 2Labuda corrections for growth are used.