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Table 2 MBL2 haplotype frequencies (%) in diverse populations.

From: Phylogenetic nomenclature and evolution of mannose-binding lectin (MBL2) haplotypes

  Afro-Gabonese (1) Afro-Americans2 German Europeans (1) Euro-Americans2 Euro-Brazilians (1)
Haplotypes N = 856 (N = 64) N = 48 N = 208 (N = 48) N = 62 N = 262
*1A1-h ( LYPA ) 16.8 (9.5) 27.1 4.81 (8.3) 1.61 3.44
*1A1.1B2-l ( LYPD ) 0 0 0 0 0.38
*1B1-h ( HYPA ) 5.37 (6.3) 6.25 29.8 (41.7) 35.5 29.39
*1B2-l ( HYPD ) 0.12 (0) 2.08 8.17 (10.4) 9.68 6.49
*1B3 0 0 0 0 0.38
*1C1-l ( LXPA ) 14.6 (18.8) 14.6 21.6 (8.3) * 16.1 20.23
*1C2 0 0 0.48 0 0
*1D1-h 3.09 (0) 0 0 0 0
*1E1-h ( LYPF ) 0.12 (0) 0 0 0 0
*1F1-l ( LYPB ) 2.45 (1.6) 2.08 11.1 (10.4) 12.9 14.89
*1F2 0 0 0 0 0
*1G1-h 0.12 (0) 0 0 0 0
*1H1-h 7.01 (3.1) 6.25 0 0 1.15
*1H2-h 0.12 (0) 0 0 0 0.38
*1J1-h 0.82 (3.1) 0 0 0 0
*2A1-h 0.7 (0) 0 0 0 0
*3A1-h 0.12 (0) 0 0 0 0
*4A1-h ( LYQA ) 25.6 (40.6) ** 18.8 23.1 (20.9) 24.2 20.99
*4B1-l ( LYQE ) 0.23 (0) 0 0 0 0
*4C1-h 0 0 0.48 (0) 0 0.76
*4D1-h 0.23 (1.6) 0 0 0 0
*4E1-h 5.37 (1.6) 6.25 0 0 0
*4F1-l ( LYQC ) 16.7 (12.5) 14.6 0 0 0.76
*4F2A-l 1.75 (1.6) 0 0.48 (0) 0 0.76
*4F2B-l 0.58 (0) 0 0 0 0
*4F3-l 1.17 (0) 2.08 0 0 0
  North Chinese 3 (1) Hispanics 2 Pacific Rim 2 Guarani 4 Kaingang 4 (1)
Haplotypes N = 348 (N = 48) N = 46 N = 48 N = 158 N = 126 (N = 26)
*1A1-h ( LYPA ) 0 6.52 2.08 0.63 1.59 (0)
*1A1.1B2-l ( LYPD ) 0 0 0 0 0
*1B1-h ( HYPA ) 54.9 (31.3) ** 28.3 45.8 48.1 52.4 (65.4)
*1B2-l ( HYPD ) 0 4.35 0 0 0
*1B3 0 0 0 0 0
*1C1-l ( LXPA ) 14.1 (22.9) 19.6 10.4 0 0.79 (0)
*1C2 0 0 0 0 0
*1D1-h 0 0 0 0 0
*1E1-h ( LYPF ) 0 0 0 0 0
*1F1-l ( LYPB ) 14.1 (29.2)& ** 13.0 16.7 47.5 26.2 (23.1)
*1F2 0 0 0 0 1.59 (0)
*1G1-h 0 0 0 0 0
*1H1-h 2.87 (4.2) 2.17 16.7 0 15.9 (11.5)
*1H2-h 0 0 0 0 0
*1J1-h 0 0 0 0 0
*2A1-h 0 0 0 0 0
*3A1-h 0 0 0 0 0
*4A1-h ( LYQA ) 14.1 (6.3) 19.6 8.33 3.8 0.79 (0)
*4B1-l ( LYQE ) 0 0 0 0 0
*4C1-h 0 0 0 0 0
*4D1-h 0 0 0 0 0
*4E1-h 0 2.17 0 0 0
*4F1-l ( LYQC ) 0 2.17 0 0 0
*4F2A-l 0 2.17 0 0 0
*4F2B-l 0 0 0 0 0
*4F3-l 0 0 0 0 0.79 (0)
  1. N number of chromosomes (N = 162 for 1D1-h in Afro-Gabonese, and this is why the sum of frequency values in this group did not equal exactly 100%). The distribution of MBL2 genotypes in the Gabonese adult sample as a whole was homogeneous with the distribution that we formerly found in a sample of 284 Gabonese children (39 malaria-free, 136 with uncomplicated malaria and 109 with severe malaria but not with cerebral malaria and/or severe hypoglycemia) [2]. In parentheses: differing values found in samples of smaller size but similar ethnic background (Gabonese Bantu, Danish, Chinese and Colombian Piapoco, respectively) [19]. & the Chinese investigated by others presented an additional LYPB haplotype with 6.3% frequency and a g.634G > A SNP (called by them -258 G > A) [19]. In italics: this work; 1 [19]; 2 [18]; 3 [28]; 4 [22].* p < 0.05 ** p < 0.01
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