Figure 1From: A modifier screen in the Drosophila eye reveals that aPKC interacts with Glued during central synapse formationThe GlDN sensitized screen in the adult eye. (A) Schematic of the screen in which UAS-GlDN males were mutagenized and crossed to GMR-GAL4 virgin females. In the F1 generation the flies were scored for any enhancement or suppression of the eye phenotype caused by over-expression of GlDN. (B-D) Scanning electron micrographs of adult eyes. (B) w; UAS-GlDN, showing a wild type eye with a regular array of ommatidia and bristles. (C) Gl1/+ exhibiting a roughened, smaller eye. (D) w; GMR-GAL4/UAS-GlDN (abbreviated to GMR>GlDN throughout) showing the much reduced and disorganized eye phenotype used as the basis for the screen. (E) shows the effects of a dominant suppressor (SG13/+) on the phenotype in (D), and (F) shows the effects of a dominant enhancer (EG37/+). (G) Gl1/+; EG162/+, showing an enhanced phenotype than for Gl1/+ alone depicted in (C).Back to article page