Schematic diagram of the breakpoints of the Koa inversion. (A) Map of mouse chromosome 15 showing positions of microsatellite markers surrounding the proximal and distal breakpoints. Numbers in parentheses indicate the position in the mouse genome sequence (Build 37.1). Markers showing hemizygosity and heterozygosity in mice with recombinant chromosomes are indicated by open and filled circles, respectively. Gray circles indicate markers used in the previous linkage analysis . A, B, C, D and E represent the corresponding regions in Figure 4. (B) Genomic structure and nucleotide sequences of the breakpoints of the Koa inversion. Underlined and double underlined letters represent deleted and inserted nucleotides at the breakpoints, respectively. Filled and gray boxes represent functional genes and predicted transcriptional units with unknown function, respectively. Arrows indicate primers for cloning of the breakpoints.