Table 3 Overview of mutations found in VKORC1 in rats, mice and humans.
Rattus norvegicus | NCBI_ss# | Mus musculus/ Mus domesticus | Homo sapiens | Reference |
|---|---|---|---|---|
Arg12Arg | 107794658 | -- | -- | this study |
-- | -- | Arg12Trp | -- | this study |
Ala21Thr | 107794659 | -- | -- | this study |
Ala26Thr | 107794660 | Ala26Ser | -- | this study |
-- | -- | -- | Val29Leu | [3] |
Arg33Pro | 107794661 | -- | -- | [13]; this study |
Arg35Pro | 107794662 | -- | -- | [14]; this study |
-- | -- | Glu37Gly | -- | this study |
Tyr39Asn | 107794663 | -- | -- | this study |
-- | -- | -- | Val45Ala | [3] |
-- | -- | Ala48Thr | -- | this study |
Ser56Pro | 107794664 | -- | -- | this study |
-- | -- | Arg58Gly | Arg58Gly | [3]; this study |
Trp59Arg | 107794665 | -- | -- | this study |
-- | -- | Arg61Leu | -- | this study |
-- | -- | -- | Val66Met | [28] |
Phe63Cys | 107794666 | -- | -- | this study |
Glu67Lys | 107794667 | -- | -- | this study |
Ile82Ile | 107794668 | -- | -- | this study |
Ile90Leu | 107794669 | -- | -- | this study |
Leu94Leu | 107794670 | -- | -- | this study |
Ser103Ser | 107794671 | -- | -- | this study |
Ile107Ile | 107794672 | -- | -- | this study |
Val112Leu | 107794673 | -- | -- | this study |
Leu120Gln | 107794674 | -- | -- | [14] |
Leu128Gln | 107794675 | Leu128Ser | Leu128Arg | |
Thr137Thr | 107794676 | -- | -- | this study |
Tyr139Phe | 107794677 | -- | -- | |
Tyr139Cys | 107794678 | Tyr139Cys | -- | |
Tyr139Ser | 107794679 | Tyr139Ser | -- | [14]; this study |
Ile141Val | 107794680 | -- | -- | this study |
Ala143Ala | 107794681 | -- | -- | this study |
Ala143Val | 107794682 | -- | -- | this study |