Table 1 VKORC1 mutations and polymorphisms found in Rattus norvegicus from different geographic areas.
Geographic area | Amino acid substitutions | No. of samples | Silent mutations | |
|---|---|---|---|---|
England | Cambridge/Essex | Phe63Cys, Ala26Thr | 1 | Ile82Ile |
Phe63Cys, Tyr39Asn | 1 | Ile82Ile | ||
Phe63Cys | 15 | Ile82Ile | ||
Norfolk | Tyr139Cys | 1 | Ile82Ile | |
Tyr139Cys | 1 | -- | ||
Gloucestershire | Tyr139Cys | 1 | -- | |
Lincolnshire | Tyr139Cys | 2 | Ile82Ile | |
Shropshire | Tyr139Ser | 2 | -- | |
Lancashire | Leu128Gln | 2 | -- | |
Nottinghamshire | Arg33Pro | 2 | -- | |
Hungary | Békés | Tyr139Cys | 1 | Ile82Ile |
-- | 2 | Ile82Ile | ||
Maglód | Tyr139Cys | 9 | not investigated | |
Azores | Terceira | Ile90Leu, Val112Leu | 2 | Leu94Leu, Ile107Ile, Thr137Thr, Ala143Ala |
Ile90Leu | 1 | Leu94Leu, Ile107Ile, Thr137Thr, Ala143Ala | ||
Ile90Leu | 1 | Ile107Ile, Thr137Thr | ||
-- | 12 | Ile82Ile | ||
Korea | Seoul | Tyr139Phe | 6 | -- |
Tyr139Phe, Ala21Thr | 1 | -- | ||
-- | 1 | Ile82Ile | ||
Indonesia | -- | 3 | Ile82Ile | |
Ile90Leu | 5 | Ile107Ile, Thr137Thr | ||
Ile90Leu, Ala143Val | 1 | Ser103Ser, Ile107Ile, Thr137Thr | ||
Ile90Leu, Ile141Val, Ala143Val | 1 | Ser103Ser, Ile107Ile, Thr137Thr | ||
Ile90Leu, Ile141Val | 6 | Ile107Ile, Thr137Thr | ||
Thailand | Ala143Val | 2 | Ser103Ser, Ile107Ile, Thr137Thr | |
Japan | Glu67Lys | 6 | -- | |
USA | Santa Cruz | Ile90Leu | 3 | Arg12Arg, Leu94Leu, Ile107Ile, Thr137Thr, Ala143Ala |
Chicago | Arg35Pro | 6 | -- | |
Arg35Pro | 8 | Ile82Ile | ||
-- | 4 | Ile82Ile | ||
Argentina | Buenos Aires | Trp59Arg, Ile90Leu | 7 | Arg12Arg, Leu94Leu, Ile107Ile, Thr137Thr, Ala143Ala |
-- | 8 | Ile82Ile |