Figure 2

Results on Type I error rate. Type I error rate of the Armitage trend test and the Mantel Statistic Using Haplotype Sharing with no (dots), differential (triangulars) and nondifferential (squares) genotype errors incorporated following the unrestricted misclassification model for different error rates per locus. With a small error rate of a) 0.2% both pointwise tests hold the nominal significance level of 0.05 (horizontal line), but with a higher error rate of b) 8% or c) 15.6% the type I error rate is dramatically increased for differential genotyping errors.