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Figure 6 | BMC Genetics

Figure 6

From: Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegans

Figure 6

smg-1(by146) and smg-6(pf52) ameliorate the phenotype of sel-12(amber) mutations. A) The fraction of animals that can lay some eggs ± the 95% confidence limits for the fraction for various smg; sel-12 strains and their controls. Values statistically significantly higher than the appropriate sel-12 control strain are indicated with a *. The number of animals that can lay some eggs is a very sensitive indicator of weak sel-12 suppression; however, most of the animals containing sel-12 mutations later became Egl. B) The mean brood size ± the 95% confidence of the mean for the strains examined in A. Values statistically significantly higher than the appropriate sel-12 control strain are indicated with a * and those values significantly lower than the appropriate control strain are indicated with **. smg; sel-12(ar131) strains may have a lower brood size than sel-12(ar131) as indicated by ?. Both smg-1(by146) and smg-6(pf52) increase the brood sizes of sel-12(amber) alleles but not that of sel-12 missense, deletion or opal alleles.

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