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  1. Alcohol dependence is a typical example of a complex trait that is governed by several genes and for which the mode of inheritance is unknown. We analyzed the microsatellite markers and the Affymetrix single-n...

    Authors: Konstantin Strauch, Robert Fürst, Franz Rüschendorf, Christine Windemuth, Johannes Dietter, Antonia Flaquer, Max P Baur and Thomas F Wienker
    Citation: BMC Genetics 2005 6(Suppl 1):S162

    This article is part of a Supplement: Volume 6 Supplement 1

  2. We report the results of statistical genetic analyses of data from the Collaborative Study on the Genetics of Alcoholism prepared for the Genetic Analysis Workshop 14 to detect and characterize maternally inhe...

    Authors: Loren R Lease, Deidre A Winnier, Jeff T Williams, Thomas D Dyer, Laura Almasy and Michael C Mahaney
    Citation: BMC Genetics 2005 6(Suppl 1):S158

    This article is part of a Supplement: Volume 6 Supplement 1

  3. P300 amplitude is an electrophysiological quantitative trait that is correlated with both alcoholism and smoking status. Using the Collaborative Study on the Genetics of Alcoholism data, we performed model-fre...

    Authors: Jocelyn F Bautista, Shannon RE Quade, Antonio R Parrado and Katrina AB Goddard
    Citation: BMC Genetics 2005 6(Suppl 1):S156

    This article is part of a Supplement: Volume 6 Supplement 1

  4. The overlap of 94 single-nucleotide polymorphisms (SNP) among the 4,720 and 11,120 SNPs contained in the linkage panels of Illumina and Affymetrix, respectively, allows an assessment of the discrepancy rate pr...

    Authors: Brian K Suarez, Chelsea Taylor, Sarah Bertelsen, Laura J Bierut, Gerald Dunn, Carol H Jin, John SK Kauwe, Andrew D Paterson and Anthony L Hinrichs
    Citation: BMC Genetics 2005 6(Suppl 1):S152

    This article is part of a Supplement: Volume 6 Supplement 1

  5. Two factors impacting robustness of the original transmission disequilibrium test (TDT) are: i) missing parental genotypes and ii) undetected genotype errors. While it is known that independently these factors...

    Authors: Sandra Barral, Chad Haynes, Mark A Levenstien and Derek Gordon
    Citation: BMC Genetics 2005 6(Suppl 1):S150

    This article is part of a Supplement: Volume 6 Supplement 1

  6. Genomic screens generally employ a single-locus strategy for linkage analysis, but this may have low power in the presence of epistasis. Ordered subsets analysis (OSA) is a method for conditional linkage analy...

    Authors: Svati H Shah, Michael A Schmidt, Hao Mei, William K Scott, Elizabeth R Hauser and Silke Schmidt
    Citation: BMC Genetics 2005 6(Suppl 1):S148

    This article is part of a Supplement: Volume 6 Supplement 1

  7. An initial linkage analysis of the alcoholism phenotype as defined by DSM-III-R criteria and alcoholism defined by DSM-IV criteria showed many, sometimes striking, inconsistencies. These inconsistencies are gr...

    Authors: Howard W Wiener, Rodney CP Go, Hemant Tiwari, Varghese George and Grier P Page
    Citation: BMC Genetics 2005 6(Suppl 1):S125

    This article is part of a Supplement: Volume 6 Supplement 1

  8. We explored the evidence for a quantitative trait locus (QTL)-specific genotype × alcoholism interaction for an evoked electroencephalogram theta band oscillation (ERP) phenotype on a region of chromosome 7 in...

    Authors: Lisa J Martin, Christy L Avery, Jeff T Williams and Kari E North
    Citation: BMC Genetics 2005 6(Suppl 1):S123

    This article is part of a Supplement: Volume 6 Supplement 1

  9. We used a maximum-likelihood based multipoint linkage approach implemented in SOLAR to examine simultaneously linkage for three electrophysiological endophenotypes from the Collaborative Study of the Genetics ...

    Authors: Diane M Warren, Thomas D Dyer, Charles P Peterson, Michael C Mahaney, John Blangero and Laura Almasy
    Citation: BMC Genetics 2005 6(Suppl 1):S117

    This article is part of a Supplement: Volume 6 Supplement 1

  10. Due to the recent gains in the availability of single-nucleotide polymorphism data, genome-wide association testing has become feasible. It is hoped that this additional data may confirm the presence of diseas...

    Authors: Amy Murphy, Matthew B McQueen, Jessica Su, Peter Kraft, Ross Lazarus, Nan M Laird, Christoph Lange and Kristel Van Steen
    Citation: BMC Genetics 2005 6(Suppl 1):S115

    This article is part of a Supplement: Volume 6 Supplement 1

  11. Genotype data from the Illumina Linkage III SNP panel (n = 4,720 SNPs) and the Affymetrix 10 k mapping array (n = 11,120 SNPs) were used to test the effects of linkage disequilibrium (LD) between SNPs in a linkag...

    Authors: Sarah Shaw Murray
    Citation: BMC Genetics 2005 6(Suppl 1):S85

    This article is part of a Supplement: Volume 6 Supplement 1

  12. Most linkage programs assume linkage equilibrium among multiple linked markers. This assumption may lead to bias for tightly linked markers where strong linkage disequilibrium (LD) exists. We used simulated da...

    Authors: Qiqing Huang, Sanjay Shete, Michael Swartz and Christopher I Amos
    Citation: BMC Genetics 2005 6(Suppl 1):S83

    This article is part of a Supplement: Volume 6 Supplement 1

  13. The haplotypes of the X chromosome are accessible to direct count in males, whereas the diplotypes of the females may be inferred knowing the haplotype of their sons or fathers. Here, we investigated: 1) the p...

    Authors: Fabio Marroni, Chiara Toni, Benedetto Pennato, Ya-Yu Tsai, Pryia Duggal, Joan E Bailey-Wilson and Silvano Presciuttini
    Citation: BMC Genetics 2005 6(Suppl 1):S77

    This article is part of a Supplement: Volume 6 Supplement 1

  14. We compared seven different tagging single-nucleotide polymorphism (SNP) programs in 10 regions with varied amounts of linkage disequilibrium (LD) and physical distance. We used the Collaborative Studies on th...

    Authors: Priya Duggal, Elizabeth M Gillanders, Rasika A Mathias, Grace P Ibay, Alison P Klein, Agnes B Baffoe-Bonnie, Liang Ou, Ian P Dusenberry, Ya-Yu Tsai, Peter S Chines, Betty Q Doan and Joan E Bailey-Wilson
    Citation: BMC Genetics 2005 6(Suppl 1):S73

    This article is part of a Supplement: Volume 6 Supplement 1

  15. This paper deals with the detection of significant linkage for quantitative traits using a variance components approach. Microsatellite markers were obtained for the Genetic Analysis Workshop 14 Collaborative ...

    Authors: Aurélie Labbe and Hanna Wormald
    Citation: BMC Genetics 2005 6(Suppl 1):S52

    This article is part of a Supplement: Volume 6 Supplement 1

  16. Many investigators of complexly inherited familial traits bypass classical segregation analysis to perform model-free genome-wide linkage scans. Because model-based or parametric linkage analysis may be the mo...

    Authors: Michael D Badzioch, Ellen L Goode and Gail P Jarvik
    Citation: BMC Genetics 2005 6(Suppl 1):S48

    This article is part of a Supplement: Volume 6 Supplement 1

  17. For linkage analysis in affected sibling pairs, we propose a regression model to incorporate information from a disease-associated single-nucleotide polymorphism located under the linkage peak. This model can ...

    Authors: Jeanine J Houwing-Duistermaat, Hae-Won Uh, Jeremie JP Lebrec, Hein Putter and Li Hsu
    Citation: BMC Genetics 2005 6(Suppl 1):S46

    This article is part of a Supplement: Volume 6 Supplement 1

  18. The purposes of this study were 1) to examine the performance of a new multimarker regression approach for model-free linkage analysis in comparison to a conventional multipoint approach, and 2) to determine t...

    Authors: Mathew J Barber, Eleanor Wheeler and Heather J Cordell
    Citation: BMC Genetics 2005 6(Suppl 1):S40

    This article is part of a Supplement: Volume 6 Supplement 1

  19. We have developed a recursive-partitioning (RP) algorithm for identifying phenotype and covariate groupings that interact with the evidence for linkage. This data-mining approach for detecting gene × environme...

    Authors: Wei Xu, Chelsea Taylor, Justin Veenstra, Shelley B Bull, Mary Corey and Celia MT Greenwood
    Citation: BMC Genetics 2005 6(Suppl 1):S38

    This article is part of a Supplement: Volume 6 Supplement 1

  20. The basic idea of affected-sib-pair (ASP) linkage analysis is to test whether the inheritance pattern of a marker deviates from Mendelian expectation in a sample of ASPs. The test depends on an assumed Mendeli...

    Authors: Pei-Ying Shih, Tao Wang, Chao Xing, Moumita Sinha, Yeunjoo Song and Robert C Elston
    Citation: BMC Genetics 2005 6(Suppl 1):S36

    This article is part of a Supplement: Volume 6 Supplement 1

  21. We compared linkage analysis results for an alcoholism trait, ALDX1 (DSM-III-R and Feigner criteria) using a nonparametric linkage analysis method, which takes into account allele sharing among several affecte...

    Authors: Ayse Ulgen and Wentian Li
    Citation: BMC Genetics 2005 6(Suppl 1):S13

    This article is part of a Supplement: Volume 6 Supplement 1

  22. We performed multipoint linkage analysis of the electrophysiological trait ECB21 on chromosome 4 in the full pedigrees provided by the Collaborative Study on the Genetics of Alcoholism (COGA). Three Markov cha...

    Authors: Weiva Sieh, Saonli Basu, Audrey Q Fu, Joseph H Rothstein, Paul A Scheet, William CL Stewart, Yun J Sung, Elizabeth A Thompson and Ellen M Wijsman
    Citation: BMC Genetics 2005 6(Suppl 1):S11

    This article is part of a Supplement: Volume 6 Supplement 1

  23. The data provided to the Genetic Analysis Workshop 14 (GAW 14) was the result of a collaboration among several different groups, catalyzed by Elizabeth Pugh from The Center for Inherited Disease Research (CIDR...

    Authors: Howard J Edenberg, Laura J Bierut, Paul Boyce, Manqiu Cao, Simon Cawley, Richard Chiles, Kimberly F Doheny, Mark Hansen, Tony Hinrichs, Kevin Jones, Mark Kelleher, Giulia C Kennedy, Guoying Liu, Gregory Marcus, Celeste McBride, Sarah Shaw Murray…
    Citation: BMC Genetics 2005 6(Suppl 1):S2

    This article is part of a Supplement: Volume 6 Supplement 1

  24. A 40-bp variable number of tandem repeats (VNTR) polymorphism exists in the 15th exon of DAT1, the gene encoding the human dopamine transporter (DAT). Though the VNTR resides in a region encoding the 3' untransla...

    Authors: Sidney H VanNess, Michael J Owens and Clinton D Kilts
    Citation: BMC Genetics 2005 6:55
  25. In the last few years, microsatellites have become the most popular molecular marker system and have intensively been applied in genome mapping, biodiversity and phylogeny studies of livestock. Compared to sin...

    Authors: Kefei Chen, Christoph Knorr, Kirsten Bornemann-Kolatzki, Jun Ren, Lusheng Huang, Gary A Rohrer and Bertram Brenig
    Citation: BMC Genetics 2005 6:54
  26. Retinoblastoma, a prototype of hereditary cancer, is the most common intraocular tumour in children and potential cause of blindness from therapeutic eye ablation, second tumours in germ line carrier's survivo...

    Authors: José R Valverde, Javier Alonso, Itziar Palacios and Ángel Pestaña
    Citation: BMC Genetics 2005 6:53
  27. Linkage studies in autism have identified susceptibility loci on chromosomes 2q and 7q, regions containing the DLX1/2 and DLX5/6 bigene clusters. The DLX genes encode homeodomain transcription factors that con...

    Authors: Steven P Hamilton, Jonathan M Woo, Elaine J Carlson, Nöel Ghanem, Marc Ekker and John LR Rubenstein
    Citation: BMC Genetics 2005 6:52
  28. Detection and evaluation of population stratification are crucial issues in the conduct of genetic association studies. Statistical approaches useful for understanding these issues have been proposed; these me...

    Authors: Bao-Zhu Yang, Hongyu Zhao, Henry R Kranzler and Joel Gelernter
    Citation: BMC Genetics 2005 6:50
  29. The molecular genetics of the P blood group system and the absence of P1 antigen in the p phenotype are still enigmatic. One theory proposes that the same gene encodes for both the P1 and Pk glycosyltransferases,...

    Authors: Åsa Hellberg, M Alan Chester and Martin L Olsson
    Citation: BMC Genetics 2005 6:49
  30. The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 – 11.4). We performed novel sequencing of the MAO ...

    Authors: Mårten Jansson, Shane McCarthy, Patrick F Sullivan, Paul Dickman, Björn Andersson, Lars Oreland, Martin Schalling and Nancy L Pedersen
    Citation: BMC Genetics 2005 6:46
  31. Human inherited diseases can be associated by genetic linkage with one or more genomic regions. The availability of the complete sequence of the human genome allows examining those locations for an associated ...

    Authors: Carolina Perez-Iratxeta, Matthias Wjst, Peer Bork and Miguel A Andrade
    Citation: BMC Genetics 2005 6:45
  32. Quantitative differences between individuals stem from a combination of genetic and environmental factors, with the heritable variation being shaped by evolutionary forces. Drosophila wing shape has emerged as an...

    Authors: Arnar Palsson, James Dodgson, Ian Dworkin and Greg Gibson
    Citation: BMC Genetics 2005 6:44
  33. Authors: Mait Metspalu, Toomas Kivisild, Ene Metspalu, Jüri Parik, Georgi Hudjashov, Katrin Kaldma, Piia Serk, Monika Karmin, Doron M Behar, M Thomas P Gilbert, Phillip Endicott, Sarabjit Mastana, Surinder S Papiha, Karl Skorecki, Antonio Torroni and Richard Villems
    Citation: BMC Genetics 2005 6:41

    The original article was published in BMC Genetics 2004 5:26

  34. Sitosterolemia is a recessively inherited disorder in humans that is associated with premature atherosclerotic disease. Mutations in ABCG5 or ABCG8, comprising the sitosterolemia locus, STSL, are now known to cau...

    Authors: Jianliang Chen, Ashok Batta, Shuqin Zheng, Wayne R Fitzgibbon, Michael E Ullian, Hongwei Yu, Patrick Tso, Gerald Salen and Shailendra B Patel
    Citation: BMC Genetics 2005 6:40
  35. The human dopamine D4 receptor (DRD4) is a candidate gene of great interest in molecular studies of human personality and psychiatric disorders. This gene is unique in having an exceptionally high amount of po...

    Authors: E Szantai, R Szmola, M Sasvari-Szekely, A Guttman and Z Ronai
    Citation: BMC Genetics 2005 6:39
  36. Africa contains the most genetically divergent group of continental populations and several studies have reported that African populations show a high degree of population stratification. In this regard, it is...

    Authors: Adebowale A Adeyemo, Guanjie Chen, Yuanxiu Chen and Charles Rotimi
    Citation: BMC Genetics 2005 6:38
  37. The picture of dog mtDNA diversity, as obtained from geographically wide samplings but from a small number of individuals per region or breed, has revealed weak geographic correlation and high degree of haplot...

    Authors: Barbara van Asch, Luísa Pereira, Filipe Pereira, Pedro Santa-Rita, Manuela Lima and António Amorim
    Citation: BMC Genetics 2005 6:37
  38. Common inbred mouse strains are genotypically diverse, but it is still poorly understood how this diversity relates to specific differences in behavior. To identify quantitative trait genes that influence tast...

    Authors: John D Boughter Jr, Sandeep Raghow, Theodore M Nelson and Steven D Munger
    Citation: BMC Genetics 2005 6:36
  39. Pinschers and other dogs with coat color dilution show a characteristic pigmentation phenotype. The fur colors are a lighter shade, e.g. silvery grey (blue) instead of black and a sandy color (Isabella fawn) i...

    Authors: Ute Philipp, Henning Hamann, Lars Mecklenburg, Seiji Nishino, Emmanuel Mignot, Anne-Rose Günzel-Apel, Sheila M Schmutz and Tosso Leeb
    Citation: BMC Genetics 2005 6:34
  40. Cultivated rice (Oryza sativa L.) is endowed with a rich genetic variability. In spite of such a great diversity, the modern rice cultivars have narrow genetic base for most of the agronomically important traits....

    Authors: Pradeep Reddy Marri, Sarla N, Laxminarayana V Reddy and EA Siddiq
    Citation: BMC Genetics 2005 6:33
  41. N-hydroxylated base analogs, such as 6-hydroxylaminopurine (HAP) and 2-amino-6-hydroxylaminopurine (AHA), are strong mutagens in various organisms due to their ambiguous base-pairing properties. The systems pro.....

    Authors: Elena I Stepchenkova, Stanislav G Kozmin, Vladimir V Alenin and Youri I Pavlov
    Citation: BMC Genetics 2005 6:31

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