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Complex traits and quantitative genetics

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

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  1. Comparisons of quantitative trait loci (QTL) for growth and parameters of growth curves assist in understanding the genetics and ultimately the physiology of growth. Records of body weight at 3, 6, 12, 24, 48 ...

    Authors: Baitsi K Podisi, Sara A Knott, David W Burt and Paul M Hocking

    Citation: BMC Genetics 2013 14:22

    Content type: Research article

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  2. Hip dysplasia remains one of the most serious hereditary diseases occurring in dogs despite long-standing evaluation schemes designed to aid selection for healthy joints. Many researchers have recommended the ...

    Authors: Thomas W Lewis, Sarah C Blott and John A Woolliams

    Citation: BMC Genetics 2013 14:16

    Content type: Research article

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  3. Selection for grain yield under drought is an efficient criterion for improving the drought tolerance of rice. Recently, some drought-tolerant rice varieties have been developed using this selection criterion ...

    Authors: Krishna Kumar Mishra, Prashant Vikram, Ram Baran Yadaw, BP Mallikarjuna Swamy, Shalabh Dixit, Ma Teresa Sta Cruz, Paul Maturan, Shailesh Marker and Arvind Kumar

    Citation: BMC Genetics 2013 14:12

    Content type: Research article

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  4. Genome-wide association studies (GWAS) have recently identified many new genetic variants associated with the development of type 2 diabetes. Many of these variants are in introns of known genes or between kno...

    Authors: Maggie M Ho, Piriya Yoganathan, Kwan Yi Chu, Subashini Karunakaran, James D Johnson and Susanne M Clee

    Citation: BMC Genetics 2013 14:10

    Content type: Research article

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  5. Knowledge of genetic markers that are correlated to stress tolerance may improve spatial mapping of reef vulnerability and can inform restoration efforts, including the choice of genotypes for breeding and res...

    Authors: Petra Lundgren, Juan C Vera, Lesa Peplow, Stephanie Manel and Madeleine JH van Oppen

    Citation: BMC Genetics 2013 14:9

    Content type: Research article

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  6. Asparagus bean (Vigna. unguiculata. ssp sesquipedalis) is a subspecies and special vegetable type of cowpea (Vigna. unguiculata L. Walp.) important in Asia. Genetic basis of horticulturally important traits of as...

    Authors: Pei Xu, Xiaohua Wu, Baogen Wang, Tingting Hu, Zhongfu Lu, Yonghua Liu, Dehui Qin, Sha Wang and Guojing Li

    Citation: BMC Genetics 2013 14:4

    Content type: Research article

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  7. This study focused on the dynamics of genome-wide effects on five milk production and eight fertility traits as well as genetic correlations between the traits. For 2,405 Holstein Friesian bulls, estimated bre...

    Authors: Eva M Strucken, Ralf H Bortfeldt, Jens Tetens, Georg Thaller and Gudrun A Brockmann

    Citation: BMC Genetics 2012 13:108

    Content type: Research article

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  8. Map-based cloning of quantitative trait loci (QTLs) in polyploidy crop species remains a challenge due to the complexity of their genome structures. QTLs for seed weight in B. napus have been identified, but info...

    Authors: Guangqin Cai, Qingyong Yang, Qian Yang, Zhenxing Zhao, Hao Chen, Jian Wu, Chuchuan Fan and Yongming Zhou

    Citation: BMC Genetics 2012 13:105

    Content type: Research article

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  9. About 9% of the offspring of a clinically healthy Piétrain boar named ‘Campus’ showed a progressive postural tremor called Campus syndrome (CPS). Extensive backcross experiments suggested a dominant mode of in...

    Authors: Leonardo Murgiano, Imke Tammen, Barbara Harlizius and Cord Drögemüller

    Citation: BMC Genetics 2012 13:99

    Content type: Research article

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  10. In crop species, QTL analysis is commonly used for identification of factors contributing to variation of agronomically important traits. As an important pasture species, a large number of QTLs have been repor...

    Authors: Hiroshi Shinozuka, Noel OI Cogan, German C Spangenberg and John W Forster

    Citation: BMC Genetics 2012 13:101

    Content type: Research article

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  12. Genomic analyses have the potential to impact selective breeding programs by identifying markers that serve as proxies for traits which are expensive or difficult to measure. Also, identifying genes affecting ...

    Authors: Caird E Rexroad III, Roger L Vallejo, Sixin Liu, Yniv Palti and Gregory M Weber

    Citation: BMC Genetics 2012 13:97

    Content type: Research article

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  14. In this study we perform a genome-wide association study (GWAS) for bovine milk fatty acids from summer milk samples. This study replicates a previous study where we performed a GWAS for bovine milk fatty acid...

    Authors: Aniek C Bouwman, Marleen HPW Visker, Johan AM van Arendonk and Henk Bovenhuis

    Citation: BMC Genetics 2012 13:93

    Content type: Research article

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  15. Slow-growing lines are widely used in France for the production of high quality free-range chickens. While such production is mainly dedicated to the whole carcass market, new prospects are opening up for the ...

    Authors: Marie Chabault, Elisabeth Baéza, Vérane Gigaud, Pascal Chartrin, Hervé Chapuis, Maryse Boulay, Cécile Arnould, François D’Abbadie, Cécile Berri and Elisabeth Le Bihan-Duval

    Citation: BMC Genetics 2012 13:90

    Content type: Research article

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  16. In this report we studied the genetic regulation of juvenile development of wildbarley introgression lines (S42ILs) under two contrasting hydroponic nitrogen (N)supplies. Ten shoot and root related traits were...

    Authors: Astrid Hoffmann, Andreas Maurer and Klaus Pillen

    Citation: BMC Genetics 2012 13:88

    Content type: Research article

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  17. Trypanosomosis, a protozoal disease affecting livestock, transmitted by Glossina (tsetse) flies is a major constraint to agricultural production in Sub-Saharan Africa. It is accepted that utilization of the nativ...

    Authors: Caleb O Orenge, Leonard Munga, Charles N Kimwele, Steve Kemp, Abraham Korol, John P Gibson, Olivier Hanotte and Morris Soller

    Citation: BMC Genetics 2012 13:87

    Content type: Research article

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  18. Pigeonpea is an important grain legume of the semi-arid tropics and sub-tropical regions where it plays a crucial role in the food and nutritional security of the people. The average productivity of pigeonpea ...

    Authors: Giriraj Kumawat, Ranjeet S Raje, Shefali Bhutani, Jitendra K Pal, Amitha SVCR Mithra, Kishor Gaikwad, Tilak R Sharma and Nagendra K Singh

    Citation: BMC Genetics 2012 13:84

    Content type: Research article

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  19. The genome-wide association study (GWAS) is a useful approach to identify genes affecting economically important traits in dairy cattle. Here, we report the results from a GWAS based on high-density SNP genoty...

    Authors: Jiazhong Guo, Hossein Jorjani and Örjan Carlborg

    Citation: BMC Genetics 2012 13:82

    Content type: Research article

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  20. We previously established a congenic mouse strain with TALLYHO/Jng (TH) donor segment on chromosome 6 in a C57BL/6 (B6) background that harbors an obesity quantitative trait locus, tabw2. The B6.TH-tabw2 congenic...

    Authors: Taryn P Stewart, Xia Mao, Maha N Aqqad, Deon Uffort, Kristy D Dillon, Arnold M Saxton and Jung Han Kim

    Citation: BMC Genetics 2012 13:81

    Content type: Research article

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  21. Recently, genome-wide association studies identified a pleiotropic gene locus, ABO, as being significantly associated with hematological traits. To confirm the effects of ABO on hematological traits, we examined ...

    Authors: Kyung-Won Hong, Sanghoon Moon, Young Jin Kim, Yun Kyoung Kim, Dong-Joon Kim, Cheong-sik Kim, Sung Soo Kim and Bong-Jo Kim

    Citation: BMC Genetics 2012 13:78

    Content type: Research article

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  22. There is often a pronounced disagreement between results obtained from different genome-wide association studies in cattle. There are multiple reasons for this disagreement. Particularly the presence of false ...

    Authors: Johanna K Höglund, Bernt Guldbrandtsen, Mogens S Lund and Goutam Sahana

    Citation: BMC Genetics 2012 13:71

    Content type: Research article

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  23. A synthetic doubled-haploid hexaploid wheat population, SynDH1, derived from the spontaneous chromosome doubling of triploid F1 hybrid plants obtained from the cross of hybrids Triticum turgidum ssp. durum line L...

    Authors: Li Zhang, Jiang-Tao Luo, Ming Hao, Lian-Quan Zhang, Zhong-Wei Yuan, Ze-Hong Yan, Ya-Xi Liu, Bo Zhang, Bao-Long Liu, Chun-Ji Liu, Huai-Gang Zhang, You-Liang Zheng and Deng-Cai Liu

    Citation: BMC Genetics 2012 13:69

    Content type: Research article

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  25. The abscisic acid (ABA) pathway plays an important role in the plants’ reaction to drought stress and ABA-stress response (Asr) genes are important in controlling this process. In this sense, we accessed nucleoti...

    Authors: Andrés J Cortés, M Carolina Chavarro, Santiago Madriñán, Dominique This and Matthew W Blair

    Citation: BMC Genetics 2012 13:58

    Content type: Research article

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  26. Neonatal cerebellar cortical degeneration is a neurodegenerative disease described in several canine breeds including the Beagle. Affected Beagles are unable to ambulate normally from the onset of walking and ...

    Authors: Oliver P Forman, Luisa De Risio, Jennifer Stewart, Cathryn S Mellersh and Elsa Beltran

    Citation: BMC Genetics 2012 13:55

    Content type: Research article

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  27. The turbot (Scophthalmus maximus) is a relevant species in European aquaculture. The small turbot genome provides a source for genomics strategies to use in order to understand the genetic basis of productive tra...

    Authors: Carmen Bouza, Miguel Hermida, Belén G Pardo, Manuel Vera, Carlos Fernández, Roberto de la Herrán, Rafael Navajas-Pérez, José Antonio Álvarez-Dios, Antonio Gómez-Tato and Paulino Martínez

    Citation: BMC Genetics 2012 13:54

    Content type: Research article

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  28. The mammalian cochlea receives and analyzes sound at specific places along the cochlea coil, commonly referred to as the tonotopic map. Although much is known about the cell-level molecular defects responsible...

    Authors: James M Keller and Konrad Noben-Trauth

    Citation: BMC Genetics 2012 13:32

    Content type: Research article

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  29. Coronary artery disease (CAD), and one of its intermediate risk factors, dyslipidemia, possess a demonstrable genetic component, although the genetic architecture is incompletely defined. We previously reporte...

    Authors: Daniel K Nolan, Beth Sutton, Carol Haynes, Jessica Johnson, Jacqueline Sebek, Elaine Dowdy, David Crosslin, David Crossman, Michael H Sketch Jr, Christopher B Granger, David Seo, Pascal Goldschmidt-Clermont, William E Kraus, Simon G Gregory, Elizabeth R Hauser and Svati H Shah

    Citation: BMC Genetics 2012 13:12

    Content type: Research article

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  30. Phytophthora infestans (Mont.) de Bary, the causal organism of late blight, is economically the most important pathogen of potato and resistance against it has been one of the primary goals of potato breeding. So...

    Authors: Jadwiga Śliwka, Henryka Jakuczun, Marcin Chmielarz, Agnieszka Hara-Skrzypiec, Iga Tomczyńska, Andrzej Kilian and Ewa Zimnoch-Guzowska

    Citation: BMC Genetics 2012 13:11

    Content type: Research article

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  31. Identification of genomic regions that have been targets of selection for phenotypic traits is one of the most important and challenging areas of research in animal genetics. However, currently there are relat...

    Authors: Mohammad Hossein Moradi, Ardeshir Nejati-Javaremi, Mohammad Moradi-Shahrbabak, Ken G Dodds and John C McEwan

    Citation: BMC Genetics 2012 13:10

    Content type: Research article

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  32. In a previously reported genome-wide association study based on a high-density bovine SNP genotyping array, 8 SNP were nominally associated (P ≤ 0.003) with average daily gain (ADG) and 3 of these were also assoc...

    Authors: Amanda K Lindholm-Perry, Andrea K Sexten, Larry A Kuehn, Timothy PL Smith, D Andy King, Steven D Shackelford, Tommy L Wheeler, Calvin L Ferrell, Thomas G Jenkins, Warren M Snelling and Harvey C Freetly

    Citation: BMC Genetics 2011 12:103

    Content type: Research article

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  33. The intramuscular fat deposition and the fatty acid profiles of beef affect meat quality. High proportions of unsaturated fatty acids are related to beef flavor and are beneficial for the nutritional value of ...

    Authors: Philipp Widmann, Karin Nuernberg, Christa Kuehn and Rosemarie Weikard

    Citation: BMC Genetics 2011 12:96

    Content type: Research article

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  34. High recombination rates have previously been detected in two groups of eusocial insects; honeybees and ants. In this study we estimate recombination rate in a eusocial wasp Vespula vulgaris that represents a thi...

    Authors: Anu Sirviö, J Spencer Johnston, Tom Wenseleers and Pekka Pamilo

    Citation: BMC Genetics 2011 12:95

    Content type: Research article

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  35. Reproductive traits, such as prolificacy, are of great interest to the pig industry. Better understanding of their genetic architecture should help to increase the efficiency of pig productivity through the im...

    Authors: Ingrid Balcells, Anna Castelló, Anna Mercadé, José L Noguera, Amanda Fernández-Rodríguez, Armand Sànchez and Anna Tomàs

    Citation: BMC Genetics 2011 12:93

    Content type: Research article

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  36. Many QTL have been detected in pigs, but very few of them have been fine-mapped up to the causal mutation. On SSC2, the IGF2-intron3-G3072A mutation has been described as the causative polymorphism for a QTL unde...

    Authors: Flavie Tortereau, Marie-Pierre Sanchez, Katia Fève, Hélène Gilbert, Nathalie Iannuccelli, Yvon Billon, Denis Milan, Jean-Pierre Bidanel and Juliette Riquet

    Citation: BMC Genetics 2011 12:92

    Content type: Research article

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  37. Drought is one of the most important abiotic stresses causing drastic reductions in yield in rainfed rice environments. The suitability of grain yield (GY) under drought as a selection criterion has been repor...

    Authors: Prashant Vikram, BP Mallikarjuna Swamy, Shalabh Dixit, Helal Uddin Ahmed, Ma Teresa Sta Cruz, Alok Kumar Singh and Arvind Kumar

    Citation: BMC Genetics 2011 12:89

    Content type: Research article

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  38. It is widely accepted that genetic variability might explain a large part of the observed heterogeneity in aerobic capacity and its response to training. Significant associations between polymorphisms of diffe...

    Authors: Tom Thomaes, Martine Thomis, Steven Onkelinx, Robert Fagard, Gert Matthijs, Roselien Buys, Dirk Schepers, Véronique Cornelissen and Luc Vanhees

    Citation: BMC Genetics 2011 12:84

    Content type: Research article

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  40. The success of genomic selection depends mainly on the extent of linkage disequilibrium (LD) between markers and quantitative trait loci (QTL), the number of animals in the training set (TS) and the heritabili...

    Authors: Fernanda V Brito, José Braccini Neto, Mehdi Sargolzaei, Jaime A Cobuci and Flavio S Schenkel

    Citation: BMC Genetics 2011 12:80

    Content type: Research article

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  41. Increased disease resistance through improved general immune capacity would be beneficial for the welfare and productivity of farm animals. T lymphocyte subpopulations in peripheral blood play an important rol...

    Authors: Xin Lu, Jian-Feng Liu, Yuan-Fang Gong, Zhi-Peng Wang, Yang Liu and Qin Zhang

    Citation: BMC Genetics 2011 12:79

    Content type: Research article

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  42. Detection of quantitative trait loci (QTLs) affecting meat quality traits in pigs is crucial for the design of efficient marker-assisted selection programs and to initiate efforts toward the identification of ...

    Authors: Pierre Cherel, José Pires, Jérôme Glénisson, Denis Milan, Nathalie Iannuccelli, Frédéric Hérault, Marie Damon and Pascale Le Roy

    Citation: BMC Genetics 2011 12:76

    Content type: Research article

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  43. Poultry production has been widely criticized for its negative environmental impact related to the quantity of manure produced and to its nitrogen and phosphorus content. In this study, we investigated which t...

    Authors: Hugues de Verdal, Agnès Narcy, Denis Bastianelli, Hervé Chapuis, Nathalie Même, Séverine Urvoix, Elisabeth Le Bihan-Duval and Sandrine Mignon-Grasteau

    Citation: BMC Genetics 2011 12:71

    Content type: Research article

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  44. Previous fine mapping studies in Norwegian Red cattle (NRC) in the region 86-90.4 Mb on Bos taurus chromosome 6 (BTA6) has revealed a quantitative trait locus (QTL) for protein yield (PY) around 88 Mb and a QTL f...

    Authors: Marte Sodeland, Harald Grove, Matthew Kent, Simon Taylor, Morten Svendsen, Ben J Hayes and Sigbjørn Lien

    Citation: BMC Genetics 2011 12:70

    Content type: Research article

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  45. Serum lipids are associated with many serious cardiovascular diseases and obesity problems. Many quantitative trait loci (QTL) have been reported in the pig mostly for performance traits but very few for the s...

    Authors: Muhammad Jasim Uddin, Do Ngoc Duy, Mehmet Ulas Cinar, Dawit Tesfaye, Ernst Tholen, Heinz Juengst, Christian Looft and Karl Schellander

    Citation: BMC Genetics 2011 12:62

    Content type: Research article

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  46. The turkey (Meleagris gallopavo) is an important agricultural species and is the second largest contributor to the world's poultry meat production. Demand of turkey meat is increasing very rapidly. Genetic marker...

    Authors: Muhammad L Aslam, John WM Bastiaansen, Richard PMA Crooijmans, Addie Vereijken and Martien AM Groenen

    Citation: BMC Genetics 2011 12:61

    Content type: Research article

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  47. Feed costs represent about 70% of the costs of raising broilers. The main way to decrease these costs is to improve feed efficiency by modification of diet formulation, but one other possibility would be to us...

    Authors: Hugues de Verdal, Agnès Narcy, Denis Bastianelli, Hervé Chapuis, Nathalie Même, Séverine Urvoix, Elisabeth Le Bihan-Duval and Sandrine Mignon-Grasteau

    Citation: BMC Genetics 2011 12:59

    Content type: Research article

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  48. The search to identify disease-susceptible genes requires access to biological material from numerous well-characterized subjects. Archived residual dried blood spot (DBS) samples, also known as Guthrie cards,...

    Authors: Mads V Hollegaard, Jakob Grove, Jonas Grauholm, Eskil Kreiner-Møller, Klaus Bønnelykke, Mette Nørgaard, Thomas L Benfield, Bent Nørgaard-Pedersen, Preben B Mortensen, Ole Mors, Henrik T Sørensen, Zitta B Harboe, Anders D Børglum, Ditte Demontis, Torben F Ørntoft, Hans Bisgaard…

    Citation: BMC Genetics 2011 12:58

    Content type: Methodology article

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  49. The intertidal zone of seacoasts, being affected by the superimposed tidal, diurnal and lunar cycles, is temporally the most complex environment on earth. Many marine organisms exhibit lunar rhythms in reprodu...

    Authors: Tobias S Kaiser, Dietrich Neumann and David G Heckel

    Citation: BMC Genetics 2011 12:49

    Content type: Research article

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  50. Identifying genomic regions, and preferably individual genes, responsible for genetic variation in milk fat composition of bovine milk will enhance the understanding of biological pathways involved in fatty ac...

    Authors: Aniek C Bouwman, Henk Bovenhuis, Marleen HPW Visker and Johan AM van Arendonk

    Citation: BMC Genetics 2011 12:43

    Content type: Research article

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