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Complex traits and quantitative genetics

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

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  1. Inducing mutations are considered to be an effective way to create novel genetic variations and hence novel agronomical traits in wheat. This study was conducted to assess the genetic differences between Shi41...

    Authors: Xuejiao Cheng, Lingling Chai, Zhaoyan Chen, Lu Xu, Huijie Zhai, Aiju Zhao, Huiru Peng, Yingyin Yao, Mingshan You, Qixin Sun and Zhongfu Ni

    Citation: BMC Genetics 2015 16:127

    Content type: Research article

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  2. Female fertility, a fundamental trait required for animal reproduction, has gradually declined in the last 2 decades in Japanese Black cattle. To identify associated genetic variants in Japanese Black cattle, ...

    Authors: Shinji Sasaki, Takayuki Ibi, Tamako Matsuhashi, Kenji Takeda, Shogo Ikeda, Mayumi Sugimoto and Yoshikazu Sugimoto

    Citation: BMC Genetics 2015 16:123

    Content type: Research article

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  3. Current evidence shows that the CD40–CD40 ligand (CD40–CD40L) system plays a crucial role in the development, progression and outcome of systemic lupus erythematosus (SLE). The aim of this study was to investi...

    Authors: Jian-Ming Chen, Jing Guo, Chuan-Dong Wei, Chun-Fang Wang, Hong-Cheng Luo, Ye-Sheng Wei and Yan Lan

    Citation: BMC Genetics 2015 16:121

    Content type: Research article

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  4. Bovine mastitis is a typical inflammatory disease causing seriously economic loss. Genome-wide association study (GWAS) can be a powerful method to promote marker assistant selection of this kind of complex di...

    Authors: Xiao Wang, Peipei Ma, Jianfeng Liu, Qin Zhang, Yuan Zhang, Xiangdong Ding, Li Jiang, Yachun Wang, Yi Zhang, Dongxiao Sun, Shengli Zhang, Guosheng Su and Ying Yu

    Citation: BMC Genetics 2015 16:111

    Content type: Research article

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  5. The Nordic Red Cattle (NRC) consists of animls belonging to the Danish Red, Finnish Ayrshire, and Swedish Red breeds. Compared to the Holstein breed, NRC animals are smaller, have a shorter calving interval, lowe...

    Authors: Johanna K. Höglund, Bart Buitenhuis, Bernt Guldbrandtsen, Mogens S. Lund and Goutam Sahana

    Citation: BMC Genetics 2015 16:110

    Content type: Research article

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  6. People with prediabetes are at greater risk for heart attack, stroke, kidney disease, vision problems, nerve damage and high blood pressure, compared to those without the disease. Prediabetes is a complex diso...

    Authors: Tran Quang Binh, Nguyen Thi Trung Thu, Pham Tran Phuong, Bui Thi Nhung and Trinh Thi Hong Nhung

    Citation: BMC Genetics 2015 16:107

    Content type: Research article

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  7. Genotype imputation has been used to increase genomic information, allow more animals in genome-wide analyses, and reduce genotyping costs. In Brazilian beef cattle production, many animals are resulting from ...

    Authors: Tatiane C. S. Chud, Ricardo V. Ventura, Flavio S. Schenkel, Roberto Carvalheiro, Marcos E. Buzanskas, Jaqueline O. Rosa, Maurício de Alvarenga Mudadu, Marcos Vinicius G. B. da Silva, Fabiana B. Mokry, Cintia R. Marcondes, Luciana C. A. Regitano and Danísio P. Munari

    Citation: BMC Genetics 2015 16:99

    Content type: Research article

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  8. Limb bone length is an economically important trait in pigs, because it is negatively correlated with backfat thickness, and is also a determinant to the yield of hip and loin. Moreover, abnormal growth of the...

    Authors: Yuanmei Guo, Lijuan Hou, Xufei Zhang, Min Huang, Huirong Mao, Hao Chen, Junwu Ma, Congying Chen, Huashui Ai, Jun Ren and Lusheng Huang

    Citation: BMC Genetics 2015 16:95

    Content type: Research article

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  10. It has been suggested that traits with low heritability, such as fertility, may have proportionately more genetic variation arising from non-additive effects than traits with higher heritability, such as milk ...

    Authors: Hassan Aliloo, Jennie E. Pryce, Oscar González-Recio, Benjamin G. Cocks and Ben J. Hayes

    Citation: BMC Genetics 2015 16:89

    Content type: Research article

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  11. In 2003 the Motor Neurone Disease (MND) Association, together with The Wellcome Trust, funded the creation of a national DNA Bank specific for MND. It was anticipated that the DNA Bank would constitute an impo...

    Authors: Lucy Smith, B. C. Cupid, B. G. M. Dickie, A. Al-Chalabi, K. E. Morrison, C. E. Shaw and P. J. Shaw

    Citation: BMC Genetics 2015 16:84

    Content type: Correspondence

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  12. Previous reports suggested a role for iron and hepcidin in atherosclerosis. Here, we evaluated the causality of these associations from a genetic perspective via (i) a Mendelian randomization (MR) approach, (i...

    Authors: Tessel E. Galesloot, Luc L. Janss, Stephen Burgess, Lambertus A. L. M. Kiemeney, Martin den Heijer, Jacqueline de Graaf, Suzanne Holewijn, Beben Benyamin, John B. Whitfield, Dorine W. Swinkels and Sita H. Vermeulen

    Citation: BMC Genetics 2015 16:79

    Content type: Research article

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  13. Soil phosphorus (P) deficiency is one of the major limiting factors to crop production. The development of crop varieties with improved P use efficiency (PUE) is an important strategy for sustainable agricultu...

    Authors: Kai Wang, Kehui Cui, Guoling Liu, Weibo Xie, Huihui Yu, Junfeng Pan, Jianliang Huang, Lixiao Nie, Farooq Shah and Shaobing Peng

    Citation: BMC Genetics 2014 15:155

    Content type: Research article

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  14. Genotype imputation is an important tool for whole-genome prediction as it allows cost reduction of individual genotyping. However, benefits of genotype imputation have been evaluated mostly for linear additiv...

    Authors: Vivian PS Felipe, Hayrettin Okut, Daniel Gianola, Martinho A Silva and Guilherme JM Rosa

    Citation: BMC Genetics 2014 15:149

    Content type: Research article

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  15. The ZFHX3 gene, located in Chromosome 16q22.3, codes for a transcription factor which is widely expressed in human tissues. Genome-wide studies have identified associations between variants within the gene and Ka...

    Authors: Ruairidh I R Martin, W Andrew Owens, Michael S Cunnington, Bongani M Mayosi, Mauro Santibáñez Koref and Bernard D Keavney

    Citation: BMC Genetics 2014 15:136

    Content type: Research article

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  16. Linkage maps are essential tools for the study of several topics in genome biology. High density linkage maps for the porcine autosomes have been constructed exploiting the high density data provided by the Po...

    Authors: Ana I Fernández, María Muñoz, Estefânia Alves, Josep María Folch, Jose Luis Noguera, Miguel Pérez Enciso, Maria del Carmen Rodríguez and Luis Silió

    Citation: BMC Genetics 2014 15:148

    Content type: Research article

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  17. Myeloproliferative neoplasms (MPNs) are a group of haematological malignancies that can be characterised by a somatic mutation (JAK2V617F). This mutation causes the bone marrow to produce excessive blood cells an...

    Authors: Su Pin Koh, Shea Ping Yip, Kwok Kuen Lee, Chi Chung Chan, Sze Man Lau, Chi Shan Kho, Chi Kuen Lau, Shek Ying Lin, Yat Ming Lau, Lap Gate Wong, Ka Leung Au, Kit Fai Wong, Raymond W Chu, Pui Hung Yu, Eudora YD Chow, Kate FS Leung…

    Citation: BMC Genetics 2014 15:147

    Content type: Research article

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  18. Global trade has ensured that the ornamental horticulture continues to grow worldwide, with rose hybrids being the most economically important genus (Rosa x hybrida). Due to changes in global trade and an increas...

    Authors: Virginia W Gitonga, Carole FS Koning-Boucoiran, Kathryn Verlinden, Oene Dolstra, Richard GF Visser, Chris Maliepaard and Frans A Krens

    Citation: BMC Genetics 2014 15:146

    Content type: Research article

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  19. Molecular diagnosis of Inherited Retinal Dystrophies (IRD) has long been challenging due to the extensive clinical and genetic heterogeneity present in this group of disorders. Here, we describe the clinical a...

    Authors: Cristina Méndez-Vidal, Nereida Bravo-Gil, María González-del Pozo, Alicia Vela-Boza, Joaquín Dopazo, Salud Borrego and Guillermo Antiñolo

    Citation: BMC Genetics 2014 15:143

    Content type: Research article

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  20. Toll-like receptors play a key role in innate immunity by recognizing pathogens and activating appropriate responses. Pathogens express several signal molecules (pathogen-associated molecular patterns, PAMPs) ...

    Authors: Flora Alfano, Simone Peletto, Maria Gabriella Lucibelli, Giorgia Borriello, Giovanna Urciuolo, Maria Grazia Maniaci, Rosanna Desiato, Michela Tarantino, Amalia Barone, Paolo Pasquali, Pier Luigi Acutis and Giorgio Galiero

    Citation: BMC Genetics 2014 15:139

    Content type: Research article

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  21. The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in t...

    Authors: Hadjira Ouhaibi-Djellouli, Sounnia Mediene-Benchekor, Sarah Aïcha Lardjam-Hetraf, Imane Hamani-Medjaoui, Djabaria Naima Meroufel, Houssam Boulenouar, Xavier Hermant, Nadhira Saidi-Mehtar, Philippe Amouyel, Leila Houti, Louisa Goumidi and Aline Meirhaeghe

    Citation: BMC Genetics 2014 15:134

    Content type: Research article

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  22. Peanut is one of the major source for human consumption worldwide and its seed contain approximately 50% oil. Improvement of oil content and quality traits (high oleic and low linoleic acid) in peanut could be...

    Authors: Manish K Pandey, Ming Li Wang, Lixian Qiao, Suping Feng, Pawan Khera, Hui Wang, Brandon Tonnis, Noelle A Barkley, Jianping Wang, C Corley Holbrook, Albert K Culbreath, Rajeev K Varshney and Baozhu Guo

    Citation: BMC Genetics 2014 15:133

    Content type: Research article

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  23. Banana shrimp Fenneropenaeus merguiensis has emerged as an important aquacultured shrimp species in South East Asia and Australia. However, the quantitative genetic basis of economically important traits in this ...

    Authors: Nguyen Hong Nguyen, Jane Quinn, Daniel Powell, Abigail Elizur, Ngo Phu Thoa, Josephine Nocillado, Robert Lamont, Courtney Remilton and Wayne Knibb

    Citation: BMC Genetics 2014 15:132

    Content type: Research article

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  24. Genomic selection and genomic wide association studies are widely used methods that aim to exploit the linkage disequilibrium (LD) between markers and quantitative trait loci (QTL). Securing a sufficiently lar...

    Authors: Renata Veroneze, John WM Bastiaansen, Egbert F Knol, Simone EF Guimarães, Fabyano F Silva, Barbara Harlizius, Marcos S Lopes and Paulo S Lopes

    Citation: BMC Genetics 2014 15:126

    Content type: Research article

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  25. The histidine ammonia-lyse gene (HAL) encodes the histidine ammonia-lyase, which catalyzes the first reaction of histidine catabolism. In our previous genome-wide association study in Chinese Holstein cows to ide...

    Authors: Haifei Wang, Li Jiang, Wenwen Wang, Shengli Zhang, Zongjun Yin, Qin Zhang and Jian-Feng Liu

    Citation: BMC Genetics 2014 15:125

    Content type: Research article

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  26. The domestic turkey (Meleagris gallopavo) is an important agricultural species that is largely used as a meat-type bird. Characterizing genetic variation in populations of domesticated species and associating the...

    Authors: Muhammad L Aslam, John WM Bastiaansen, Hendrik-Jan Megens, Richard PMA Crooijmans, Fozia Nasreen, Le Ann Blomberg, Curtis P Van Tassell, Tad S Sonstegard, Steven G Schroeder, Martien AM Groenen and Julie A Long

    Citation: BMC Genetics 2014 15:117

    Content type: Research article

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  27. High temperature (heat) stress during grain filling is a major problem in most of the wheat growing areas. Developing heat tolerant cultivars has become a principal breeding goal in the Southern and Central Gr...

    Authors: Shyamal Krishna Talukder, Md Ali Babar, Kolluru Vijayalakshmi, Jesse Poland, Pagadala Venkata Vara Prasad, Robert Bowden and Allan Fritz

    Citation: BMC Genetics 2014 15:97

    Content type: Research article

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  28. There is growing evidence that the ghrelin axis, including ghrelin (GHRL) and its receptor, the growth hormone secretagogue receptor (GHSR), play a role in cancer progression. Ghrelin gene and ghrelin receptor ge...

    Authors: Noel A Pabalan, Inge Seim, Hamdi Jarjanazi and Lisa K Chopin

    Citation: BMC Genetics 2014 15:118

    Content type: Research article

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  29. The rearrangements in the 22q11.2 chromosomal region, responsible for the 22q11.2 deletion and microduplication syndromes, are frequently associated with congenital heart disease (CHD). The present work aimed ...

    Authors: Renato Pires, Lu’s M Pires, Sara O Vaz, Paula Maciel, Rui Anjos, Raquel Moniz, Claudia C Branco, Rita Cabral, Isabel M Carreira and Luisa Mota-Vieira

    Citation: BMC Genetics 2014 15:115

    Content type: Research article

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  30. How to map quantitative trait loci (QTL) with epistasis efficiently and reliably has been a persistent problem for QTL mapping analysis. There are a number of difficulties for studying epistatic QTL. Linkage c...

    Authors: Cecelia Laurie, Shengchu Wang, Luciana Aparecida Carlini-Garcia and Zhao-Bang Zeng

    Citation: BMC Genetics 2014 15:112

    Content type: Research Article

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  31. Growth and carcass traits are very important traits for broiler chickens. However, carcass traits can only be measured postmortem. Genomic selection may be a powerful tool for such traits because of its accura...

    Authors: Tianfei Liu, Hao Qu, Chenglong Luo, Dingming Shu, Jie Wang, Mogens Sandø Lund and Guosheng Su

    Citation: BMC Genetics 2014 15:110

    Content type: Research article

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  32. Root is the prime organ that sucks water and nutrients from deep layer of soil. Wild barley diversity exhibits remarkable variation in root system architecture that seems crucial in its adaptation to abiotic s...

    Authors: Ali Ahmad Naz, Md Arifuzzaman, Shumaila Muzammil, Klaus Pillen and Jens Léon

    Citation: BMC Genetics 2014 15:107

    Content type: Research article

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  33. Mastitis is a major disease of dairy cattle occurring in response to environmental exposure to infective agents with a great economic impact on dairy industry. Somatic cell count (SCC) and its log transformati...

    Authors: Maria G Strillacci, Erika Frigo, Fausta Schiavini, Antonia B Samoré, Fabiola Canavesi, Mario Vevey, Maria C Cozzi, Morris Soller, Ehud Lipkin and Alessandro Bagnato

    Citation: BMC Genetics 2014 15:106

    Content type: Research article

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  35. Feed efficiency is jointly determined by productivity and feed requirements, both of which are economically relevant traits in beef cattle production systems. The objective of this study was to identify genes/...

    Authors: Priscila SN de Oliveira, Aline SM Cesar, Michele L do Nascimento, Amália S Chaves, Polyana C Tizioto, Rymer R Tullio, Dante PD Lanna, Antonio N Rosa, Tad S Sonstegard, Gerson B Mourao, James M Reecy, Dorian J Garrick, Maurício A Mudadu, Luiz L Coutinho and Luciana CA Regitano

    Citation: BMC Genetics 2014 15:100

    Content type: Research article

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  36. Hyperphosphatemic Familial Tumoral Calcinosis (HFTC) and Hyperphosphatemic Hyperostosis Syndrome (HHS) are associated with autosomal recessive mutations in three different genes, FGF23, GALNT3 and KL, leading to ...

    Authors: Silje Rafaelsen, Stefan Johansson, Helge Ræder and Robert Bjerknes

    Citation: BMC Genetics 2014 15:98

    Content type: Research article

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  37. A susceptibility locus, Nidd2n, for type 2 diabetes has been mapped to mouse chromosome 14 (Chr 14) and confirmed using the consomic strain (C3H-Chr 14NSY) of the Nagoya-Shibata-Yasuda (NSY) mouse, an animal mode...

    Authors: Naru Babaya, Hironori Ueda, Shinsuke Noso, Yoshihisa Hiromine, Michiko Itoi-Babaya, Misato Kobayashi, Tomomi Fujisawa and Hiroshi Ikegami

    Citation: BMC Genetics 2014 15:93

    Content type: Research article

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  38. Neural tube defects (NTDs) are the second most common birth defect in humans. Dietary folic acid (FA) supplementation effectively and safely reduces the incidence of these often debilitating congenital anomali...

    Authors: Ghunwa A Nakouzi and Joseph H Nadeau

    Citation: BMC Genetics 2014 15:91

    Content type: Research article

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  39. Genomic information can be used to predict not only continuous but also categorical (e.g. binomial) traits. Several traits of interest in human medicine and agriculture present a discrete distribution of pheno...

    Authors: Filippo Biscarini, Piergiorgio Stevanato, Chiara Broccanello, Alessandra Stella and Massimo Saccomani

    Citation: BMC Genetics 2014 15:87

    Content type: Research article

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  40. Hyperuricemia is associated with multiple diseases, including gout, cardiovascular disease, and renal disease. Serum urate is highly heritable, yet association studies of single nucleotide polymorphisms (SNPs)...

    Authors: Robert B Scharpf, Lynn Mireles, Qiong Yang, Anna Köttgen, Ingo Ruczinski, Katalin Susztak, Eitan Halper-Stromberg, Adrienne Tin, Stephen Cristiano, Aravinda Chakravarti, Eric Boerwinkle, Caroline S Fox, Josef Coresh and Wen Hong Linda Kao

    Citation: BMC Genetics 2014 15:81

    Content type: Research article

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  42. Patellar luxation is an orthopedic disorder in which the patella moves out of its normal location within the femoral trochlea of the knee and it can lead to osteoarthritis, lameness, and pain. In dogs it is a ...

    Authors: Ineke C M Lavrijsen, Peter A J Leegwater, Chalika Wangdee, Frank G van Steenbeek, Monique Schwencke, Gert J Breur, Freek J Meutstege, Isaac J Nijman, Edwin Cuppen, Henri C M Heuven and Herman A W Hazewinkel

    Citation: BMC Genetics 2014 15:64

    Content type: Research article

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  43. Drought is one of the most important abiotic stresses that cause drastic reduction in rice grain yield (GY) in rainfed environments. The identification and introgression of QTL leading to high GY under drought...

    Authors: Nitika Sandhu, Anshuman Singh, Shalabh Dixit, Ma Teresa Sta Cruz, Paul Cornelio Maturan, Rajinder Kumar Jain and Arvind Kumar

    Citation: BMC Genetics 2014 15:63

    Content type: Research article

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  44. Genome-wide association studies have identified variants associated with obesity-related traits, such as the body mass index (BMI). We sought to determine how the combination of 31 validated, BMI-associated lo...

    Authors: Louisa Goumidi, Dominique Cottel, Jean Dallongeville, Philippe Amouyel and Aline Meirhaeghe

    Citation: BMC Genetics 2014 15:62

    Content type: Research article

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  45. Gray leaf spot (GLS) is a globally important foliar disease of maize. Cercospora zeina, one of the two fungal species that cause the disease, is prevalent in southern Africa, China, Brazil and the eastern corn be...

    Authors: Dave K Berger, Maryke Carstens, Jeanne N Korsman, Felix Middleton, Frederik J Kloppers, Pangirayi Tongoona and Alexander A Myburg

    Citation: BMC Genetics 2014 15:60

    Content type: Research article

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  46. Plant height is a prime example of a dynamic trait that changes constantly throughout adult development. In this study we utilised a large triticale mapping population, comprising 647 doubled haploid lines der...

    Authors: Tobias Würschum, Wenxin Liu, Lucas Busemeyer, Matthew R Tucker, Jochen C Reif, Elmar A Weissmann, Volker Hahn, Arno Ruckelshausen and Hans Peter Maurer

    Citation: BMC Genetics 2014 15:59

    Content type: Research article

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  47. The C34T genetic polymorphism (rs17602729) in the AMPD1 gene, encoding the skeletal muscle-specific isoform of adenosine monophosphate deaminase (AMPD1), is a common polymorphism among Caucasians that can impair ...

    Authors: Valentina Ginevičienė, Audronė Jakaitienė, Aidas Pranculis, Kazys Milašius, Linas Tubelis and Algirdas Utkus

    Citation: BMC Genetics 2014 15:58

    Content type: Research article

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  49. Refractive errors and high myopia are the most common ocular disorders, and both of them are leading causes of blindness in the world. Recently, genetic association studies in European and Japanese population ...

    Authors: Yu Qiang, Wenjin Li, Qingzhong Wang, Kuanjun He, Zhiqiang Li, Jianhua Chen, Zhijian Song, Jia Qu, Xiangtian Zhou, Shengying Qin, Jiawei Shen, Zujia Wen, Jue Ji and Yongyong Shi

    Citation: BMC Genetics 2014 15:51

    Content type: Research article

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  50. Chalkiness is a major constraint in rice production because it is one of the key factors determining grain quality (appearance, processing, milling, storing, eating, and cooking quality) and price. Its reducti...

    Authors: Bo Peng, Lingqiang Wang, Chuchuan Fan, Gonghao Jiang, Lijun Luo, Yibo Li and Yuqing He

    Citation: BMC Genetics 2014 15:49

    Content type: Research article

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