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Complex traits and quantitative genetics

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

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  1. Increasing grain yield is a primary objective of maize breeding. Dissecting the genetic architecture of grain yield furthers genetic improvements to increase yield. Presented here is an association panel compo...

    Authors: Ting Li, Jianzhou Qu, Yahui Wang, Liguo Chang, Kunhui He, Dongwei Guo, Xinghua Zhang, Shutu Xu and Jiquan Xue

    Citation: BMC Genetics 2018 19:63

    Content type: Research article

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  2. The changing climate is altering timing of key fruit ripening processes and increasing the occurrence of fruit defects. To improve our understanding of the genetic control of raspberry fruit development an enh...

    Authors: Christine A. Hackett, Linda Milne, Kay Smith, Pete Hedley, Jenny Morris, Craig G. Simpson, Katharine Preedy and Julie Graham

    Citation: BMC Genetics 2018 19:59

    Content type: Research article

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  3. Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, heterozygous females could also manifest hemolytic crisis, neonatal hyperbilirubinemia or kernicterus upon expos...

    Authors: Md Tarikul Islam, Suprovath Kumar Sarker, Shezote Talukder, Golam Sarower Bhuyan, Asifuzzaman Rahat, Nafisa Nawal Islam, Hasan Mahmud, Mohammad Amir Hossain, A. K. M. Muraduzzaman, Jakia Rahman, Syeda Kashfi Qadri, Mohammod Shahidullah, Mohammad Abdul Mannan, Sarabon Tahura, Manzoor Hussain, Narayan Saha…

    Citation: BMC Genetics 2018 19:58

    Content type: Methodology article

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  4. Rolling of leaves (RL) is a phenomenon commonly found in grasses. Morphology of the leaf is an important agronomic trait in field crops especially in rice; therefore, majority of the rice breeders are interest...

    Authors: Beata Myśków, Magdalena Góralska, Natalia Lenarczyk, Ilona Czyczyło-Mysza and Stefan Stojałowski

    Citation: BMC Genetics 2018 19:57

    Content type: Research article

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  7. Many common and relevant diseases affecting equine welfare have yet to be tested regarding structural variants such as copy number variations (CNVs). CNVs make up a substantial proportion of total genetic vari...

    Authors: Anouk Schurink, Vinicius H. da Silva, Brandon D. Velie, Bert W. Dibbits, Richard P. M. A. Crooijmans, Liesbeth Franҫois, Steven Janssens, Anneleen Stinckens, Sarah Blott, Nadine Buys, Gabriella Lindgren and Bart J. Ducro

    Citation: BMC Genetics 2018 19:49

    Content type: Research article

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  8. Photobacteriosis is an infectious disease developed by a Gram-negative bacterium Photobacterium damselae subsp. piscicida (Phdp), which may cause high mortalities (90–100%) in sea bream. Selection and breeding fo...

    Authors: Muhammad L Aslam, Roberta Carraro, Anastasia Bestin, Sophie Cariou, Anna K. Sonesson, Jean-Sébastien Bruant, Pierrick Haffray, Luca Bargelloni and Theo H. E. Meuwissen

    Citation: BMC Genetics 2018 19:43

    Content type: Research article

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  9. Anterior cruciate ligament rupture (ACLR) is a debilitating and potentially life-changing condition in humans, as there is a high prevalence of early-onset osteoarthritis after injury. Identification of high-r...

    Authors: Lauren A. Baker, Guilherme J. M. Rosa, Zhengling Hao, Alexander Piazza, Christopher Hoffman, Emily E. Binversie, Susannah J. Sample and Peter Muir

    Citation: BMC Genetics 2018 19:39

    Content type: Research article

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  11. Currently, genome-wide scans for positive selection signatures in commercial breed have been investigated. However, few studies have focused on selection footprints of indigenous breeds. Laiwu pig is an invalu...

    Authors: Minhui Chen, Jiying Wang, Yanping Wang, Ying Wu, Jinluan Fu and Jian-feng Liu

    Citation: BMC Genetics 2018 19:31

    Content type: Research article

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  12. Genome-wide association studies (GWAS) have been successfully implemented in cattle research and breeding. However, moving from the associations to identifying the causal variants and revealing underlying mech...

    Authors: Zexi Cai, Bernt Guldbrandtsen, Mogens Sandø Lund and Goutam Sahana

    Citation: BMC Genetics 2018 19:30

    Content type: Methodology article

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    The Retraction Note to this article has been published in BMC Genetics 2018 19:111

  13. One of the major impediments to spiny lobster aquaculture is the high cost of hatchery production due to the long and complex larval cycle and poor survival during the many moult stages, especially at metamorp...

    Authors: Nguyen H. Nguyen, Quinn P. Fitzgibbon, Jane Quinn, Greg Smith, Stephen Battaglene and Wayne Knibb

    Citation: BMC Genetics 2018 19:27

    Content type: Research article

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  15. Sweet cherry is consumed widely across the world and provides substantial economic benefits in regions where it is grown. While cherry breeding has been conducted in the Pacific Northwest for over half a centu...

    Authors: Julia Piaskowski, Craig Hardner, Lichun Cai, Yunyang Zhao, Amy Iezzoni and Cameron Peace

    Citation: BMC Genetics 2018 19:23

    Content type: Research article

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  16. During the last two decades, many QTL (quantitative trait locus) mapping experiments in pigs have been conducted using F2 crosses established from two outbred founder breeds. The founder breeds were frequently...

    Authors: Markus Schmid, Robin Wellmann and Jörn Bennewitz

    Citation: BMC Genetics 2018 19:22

    Content type: Research article

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  17. Calving difficulty or dystocia has a great economic impact in the US dairy industry. Reported risk factors associated with calving difficulty are feto-pelvic disproportion, gestation length and conformation. D...

    Authors: Francesco Tiezzi, Maria E. Arceo, John B. Cole and Christian Maltecca

    Citation: BMC Genetics 2018 19:20

    Content type: Research article

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  18. Spotted wilt, caused by tomato spotted wilt virus (TSWV), has been one of major diseases in cultivated peanut grown in the southeastern United States (US) since 1990. Previously a major quantitative trait locus (...

    Authors: Zifan Zhao, Yu-Chien Tseng, Ze Peng, Yolanda Lopez, Charles Y. Chen, Barry L. Tillman, Phat Dang and Jianping Wang

    Citation: BMC Genetics 2018 19:17

    Content type: Research article

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  19. Syringomyelia (SM) is a common condition affecting brachycephalic toy breed dogs and is characterized by the development of fluid-filled cavities within the spinal cord. It is often concurrent with a complex d...

    Authors: Frédéric Ancot, Philippe Lemay, Susan P. Knowler, Karen Kennedy, Sandra Griffiths, Giunio Bruto Cherubini, Jane Sykes, Paul J. J. Mandigers, Guy A. Rouleau, Clare Rusbridge and Zoha Kibar

    Citation: BMC Genetics 2018 19:16

    Content type: Research article

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  20. Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins a...

    Authors: Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. Jørgensen, Kristine Færch, Daniel R. Witte, Jens J. Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K. Kanters and Torben Hansen

    Citation: BMC Genetics 2018 19:15

    Content type: Research article

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  21. Service sire has a considerable impact on reproductive success in dairy cattle. Most gene mapping studies for bull fertility have focused on additive effects, while non-additive effects have been largely ignor...

    Authors: Paula Nicolini, Rocío Amorín, Yi Han and Francisco Peñagaricano

    Citation: BMC Genetics 2018 19:14

    Content type: Research article

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  22. Diversity in crops is fundamental for plant breeding efforts. An accurate assessment of genetic diversity, using molecular markers, such as single nucleotide polymorphism (SNP), must be able to reveal the stru...

    Authors: Martin E. Tagliotti, Sofia I. Deperi, Maria C. Bedogni, Ruofang Zhang, Norma C. Manrique Carpintero, Joseph Coombs, David Douches and Marcelo A. Huarte

    Citation: BMC Genetics 2018 19:8

    Content type: Research article

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  23. The development of next-generation sequencing technologies has facilitated the identification of rare variants. Family-based design is commonly used to effectively control for population admixture and substruc...

    Authors: Yumei Li, Yang Xiang, Chao Xu, Hui Shen and Hongwen Deng

    Citation: BMC Genetics 2018 19:7

    Content type: Methodology article

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  24. Bangladesh lies in the global thalassemia belt, which has a defined mutational hot-spot in the beta-globin gene. The high carrier frequencies of beta-thalassemia trait and hemoglobin E-trait in Bangladesh nece...

    Authors: Md Tarikul Islam, Suprovath Kumar Sarkar, Nusrat Sultana, Mst. Noorjahan Begum, Golam Sarower Bhuyan, Shezote Talukder, A. K. M. Muraduzzaman, Md Alauddin, Mohammad Sazzadul Islam, Pritha Promita Biswas, Aparna Biswas, Syeda Kashfi Qadri, Tahmina Shirin, Bilquis Banu, Salma Sadya, Manzoor Hussain…

    Citation: BMC Genetics 2018 19:1

    Content type: Research article

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  25. Osteoarthritis (OA) is the most common degenerative joint disease afflicting people in the Western world and has a strong genetic influence. The aim of this study was to examine the association of two known fu...

    Authors: Mari Taipale, Svetlana Solovieva, Päivi Leino-Arjas and Minna Männikkö

    Citation: BMC Genetics 2017 18:108

    Content type: Research article

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  26. Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop C...

    Authors: Jasmin Divers, Nicholette D. Palmer, Carl D. Langefeld, W. Mark Brown, Lingyi Lu, Pamela J. Hicks, S. Carrie Smith, Jianzhao Xu, James G. Terry, Thomas C. Register, Lynne E. Wagenknecht, John S. Parks, Lijun Ma, Gary C. Chan, Sarah G. Buxbaum, Adolfo Correa…

    Citation: BMC Genetics 2017 18:105

    Content type: Research article

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  27. Repeat breeding, which is defined as cattle failure to conceive after three or more inseminations in the absence of clinical abnormalities, is a substantial problem in cattle breeding. To identify maternal gen...

    Authors: Taichi Arishima, Shinji Sasaki, Tomohiro Isobe, Yoshihisa Ikebata, Shinichi Shimbara, Shogo Ikeda, Keisuke Kawashima, Yutaka Suzuki, Manabu Watanabe, Sumio Sugano, Kazunori Mizoshita and Yoshikazu Sugimoto

    Citation: BMC Genetics 2017 18:103

    Content type: Research article

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  28. Ritodrine, a tocolytic β2-agonist, has been used extensively in Europe and Asia despite its safety concerns. This study was designed to identify associations between β2-adrenergic receptor (ADRB2) polymorphisms a...

    Authors: Jee Eun Chung, Soo An Choi, Han Sung Hwang, Jin Young Park, Kyung Eun Lee, Jeong Yee, Young Ju Kim and Hye Sun Gwak

    Citation: BMC Genetics 2017 18:96

    Content type: Research article

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  29. Recent advances in the mapping of biochemical traits have been reported in Lolium perenne. Although the mapped traits, including individual sugars and fatty acids, contribute greatly towards ruminant productivity...

    Authors: Alexandre Foito, Christine Anne Hackett, Derek Stewart, Janaki Velmurugan, Dan Milbourne, Stephen L. Byrne and Susanne Barth

    Citation: BMC Genetics 2017 18:84

    Content type: Research article

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  30. Understanding the relationship between genetic admixture and performances is crucial for the success of crossbreeding programs. Use of small sets of ancestry informative markers (AIMs) is a cost effective opti...

    Authors: Tesfaye Getachew, Heather J. Huson, Maria Wurzinger, Jörg Burgstaller, Solomon Gizaw, Aynalem Haile, Barbara Rischkowsky, Gottfried Brem, Solomon Antwi Boison, Gábor Mészáros, Ally Okeyo Mwai and Johann Sölkner

    Citation: BMC Genetics 2017 18:80

    Content type: Research article

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  31. Surveillance for bovine genetic diseases in Denmark identified a hitherto unreported congenital syndrome occurring among progeny of a Holstein sire used for artificial breeding. A genetic aetiology due to a do...

    Authors: Jørgen S. Agerholm, Fintan J. McEvoy, Steffen Heegaard, Carole Charlier, Vidhya Jagannathan and Cord Drögemüller

    Citation: BMC Genetics 2017 18:74

    Content type: Research article

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  32. Piglet splay leg syndrome (PSL) is one of the most frequent genetic defects, and can cause considerable economic loss in pig production. The present understanding of etiology and pathogenesis of PSL is poor. T...

    Authors: Xingjie Hao, Graham Plastow, Chunyan Zhang, Sutong Xu, Zhiqiu Hu, Tianfu Yang, Kai Wang, Huawei Yang, Xiaoxue Yin, Shili Liu, Zhenghua Wang, Zhiquan Wang and Shujun Zhang

    Citation: BMC Genetics 2017 18:64

    Content type: Research article

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  33. Using a genome-wide association study strategy, our previous study discovered 19 significant single-nucleotide polymorphisms (SNPs) related to semen production traits in Chinese Holstein bulls. Among them, thr...

    Authors: Shuli Liu, Hongwei Yin, Cong Li, Chunhua Qin, Wentao Cai, Mingyue Cao and Shengli Zhang

    Citation: BMC Genetics 2017 18:63

    Content type: Research article

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  34. Quantitative traits are common in nature, but quantitative pathogenicity has received only little attention in phytopathology. In this study, we used 100 Fusarium culmorum isolates collected from natural field en...

    Authors: Valheria Castiblanco, Jose J. Marulanda, Tobias Würschum and Thomas Miedaner

    Citation: BMC Genetics 2017 18:49

    Content type: Research article

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  35. Differential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to th...

    Authors: Hemant Kulkarni, Manju Mamtani, Gerard Wong, Jacquelyn M. Weir, Christopher K. Barlow, Thomas D. Dyer, Laura Almasy, Michael C. Mahaney, Anthony G. Comuzzie, Ravindranath Duggirala, Peter J. Meikle, John Blangero and Joanne E. Curran

    Citation: BMC Genetics 2017 18:48

    Content type: Research article

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  36. Due to the great advantages in selection accuracy and efficiency, genomic selection (GS) has been widely studied in livestock, crop and aquatic animals. Our previous study based on one full-sib family of Litopena...

    Authors: Quanchao Wang, Yang Yu, Jianbo Yuan, Xiaojun Zhang, Hao Huang, Fuhua Li and Jianhai Xiang

    Citation: BMC Genetics 2017 18:45

    Content type: Research article

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  37. Eye pigmentation abnormalities in cattle are often related to albinism, Chediak-Higashi or Tietz like syndrome. However, mutations only affecting pigmentation of coat color and eye have also been described. He...

    Authors: Anne K. Hollmann, Martina Bleyer, Andrea Tipold, Jasmin N. Neßler, Wilhelm E. Wemheuer, Ekkehard Schütz and Bertram Brenig

    Citation: BMC Genetics 2017 18:30

    Content type: Research article

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  38. The significant social and economic loss as a result of bovine tuberculosis (bTB) presents a continuous challenge to cattle industries in the UK and worldwide. However, host genetic variation in cattle suscept...

    Authors: Kethusegile Raphaka, Oswald Matika, Enrique Sánchez-Molano, Raphael Mrode, Mike Peter Coffey, Valentina Riggio, Elizabeth Janet Glass, John Arthur Woolliams, Stephen Christopher Bishop and Georgios Banos

    Citation: BMC Genetics 2017 18:27

    Content type: Research article

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  39. With the development of SNP chips, SNP information provides an efficient approach to further disentangle different patterns of genomic variances and covariances across the genome for traits of interest. Due to...

    Authors: Xiujin Li, Mogens Sandø Lund, Luc Janss, Chonglong Wang, Xiangdong Ding, Qin Zhang and Guosheng Su

    Citation: BMC Genetics 2017 18:26

    Content type: Research article

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  40. Potato frying color is an agronomic trait influenced by the sugar content of tubers. The candidate gene approach was employed to elucidate the molecular basis of this trait in Solanum tuberosum Group Phureja, whi...

    Authors: Diana Duarte-Delgado, Deissy Juyó, Christiane Gebhardt, Felipe Sarmiento and Teresa Mosquera-Vásquez

    Citation: BMC Genetics 2017 18:23

    Content type: Research article

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    The Correction to this article has been published in BMC Genetics 2017 18:91

  41. Milk β-lactoglobulin (β-LG) content is of interest as it is associated with nutritional and manufacturing properties. It is known that milk β-LG content is strongly affected by genetic factors. In cattle, most...

    Authors: Nicolas Bedere and Henk Bovenhuis

    Citation: BMC Genetics 2017 18:17

    Content type: Research article

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  42. Recent advances in the development of sequencing technologies provide researchers with unprecedented possibilities for genetic analyses. In this review, we will discuss the history of genetic studies and the p...

    Authors: Britt-Sabina Petersen, Broder Fredrich, Marc P. Hoeppner, David Ellinghaus and Andre Franke

    Citation: BMC Genetics 2017 18:14

    Content type: Review

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  43. One of the most commonly used quality measurements of pork is pH measured 24 h after slaughter. The most probable mode of inheritance for this trait is oligogenic with several known major genes, such as PRKAG3. I...

    Authors: Lucas L. Verardo, Marja-Liisa Sevón-Aimonen, Timo Serenius, Ville Hietakangas and Pekka Uimari

    Citation: BMC Genetics 2017 18:13

    Content type: Research article

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  44. Idiopathic or genetic adult-onset epilepsy is a common neurological disorder in domestic dogs. Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we ...

    Authors: Lotta L. E. Koskinen, Eija H. Seppälä, Jutta Weissl, Tarja S. Jokinen, Ranno Viitmaa, Reetta L. Hänninen, Pascale Quignon, Andrea Fischer, Catherine André and Hannes Lohi

    Citation: BMC Genetics 2017 18:8

    Content type: Research article

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  45. FTO gene variants have been associated with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and elite athlete phenotypes.

    Authors: S. M. Heffernan, G. K. Stebbings, L. P. Kilduff, R. M. Erskine, S. H. Day, C. I. Morse, J. S. McPhee, C. J. Cook, B. Vance, W. J. Ribbans, S. M. Raleigh, C. Roberts, M. A. Bennett, G. Wang, M. Collins, Y. P. Pitsiladis…

    Citation: BMC Genetics 2017 18:4

    Content type: Research article

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  46. Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disease caused by interactions between environmental and genetic factors. The SMXA-5 mouse is a high-fat diet-induced fatty liver model established ...

    Authors: Miyako Suzuki, Misato Kobayashi, Tamio Ohno, Shinsaku Kanamori, Soushi Tateishi, Atsushi Murai and Fumihiko Horio

    Citation: BMC Genetics 2016 17:145

    Content type: Research article

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  48. Among SNP markers that become increasingly valuable in molecular breeding of crop plants are the CAPS and dCAPS markers derived from the genes of interest. To date, the number of such gene-based markers is sma...

    Authors: Fakhriddin N. Kushanov, Alan E. Pepper, John Z. Yu, Zabardast T. Buriev, Shukhrat E. Shermatov, Sukumar Saha, Mauricio Ulloa, Johnie N. Jenkins, Abdusattor Abdukarimov and Ibrokhim Y. Abdurakhmonov

    Citation: BMC Genetics 2016 17:141

    Content type: Research article

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  49. The use of wood as an industrial raw material has led to development of plantation forestry, in which trees are planted, managed, and harvested as crops. The productivity of such plantations often exceeds that...

    Authors: Jin S. Xiong, Steven E. McKeand, Fikret Isik, Jill Wegrzyn, David B. Neale, Zhao-Bang Zeng, Luciano da Costa e Silva and Ross W. Whetten

    Citation: BMC Genetics 2016 17:138

    Content type: Research article

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  50. Recombination rate is an essential parameter for many genetic analyses. Recombination rates are highly variable across species, populations, individuals and different genomic regions. Due to the profound influ...

    Authors: Marinela Dukić, Daniel Berner, Marius Roesti, Christoph R. Haag and Dieter Ebert

    Citation: BMC Genetics 2016 17:137

    Content type: Research article

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