Table 1 Participant characteristics in AugUR (n = 2,272) and KORA S4 (n = 2,900). Shown are the characteristics of the AugUR study where all individuals are > 70 years old and the KORA S4 study restricted to participants < 70 years, in order to have a fully distinct age range in the two otherwise comparable studies. Values are given as mean with standard deviation or as percentage and number; range of phenotype trait is given for all continuous traits

Age [years]

78.4 ± 5.0

70, 95

46.2 ± 12.6

24, 69

Women

51.5% (n = 1,170)

-

52.8% (n = 1,532)

-

BMI [kg/m²]^a

27.7 ± 4.5

15.66, 52.99

26.8 ± 4.7

15.8, 55.1

Education [years]^b

12.3 ± 3.4

6, 23

11.79 ± 2.64

8, 17

Never smoking

55.5% (n = 1,258)

-

41.1% (n = 1,193)

Former smoking

39.2% (n = 888)

-

31.7% (n = 919)

Current smoking

5.3% (n = 119)

-

27.2% (n = 788)

CAD^c

15.5% (n = 351)

-

1.7% (n = 49)

-

Diabetes^d

20.9% (n = 474)

-

3.1% (n = 89)

-

Antidiabetics

16.3% (n = 371)

-

2.6% (n = 74)

Hypertension^e

72.7% (n = 1,651)

-

32.0% (n = 927)

-

Antihypertensives

67.5% (n = 1,534)

-

13.6% (n = 395)

-

Heart failure^f

14.7% (n = 335)

-

2.2% (n = 64)

-

High-ceiling diuretics

12.8% (n = 290)

-

1.3% (n = 38)

Creatinine (serum) [mg/dL]

0.9 ± 0.3

0.4, 5.2

0.8 ± 0.2

0.4, 2.2

eGFR_crea^g[mL/min/1.73m²]

67.7 ± 15.9

9.9, 106.7

95.3 ± 15.5

24.3, 133.9

Cystatin C (serum) [mg/L]

1.2 ± 0.3

0.7, 5.2

0.8 ± 0.2

0.14, 3.3

eGFR_cys^h [

mL/min/1.73m²]

60.9 ± 16.8

8.5, 106.3

99.2 ± 18.1

15.4, 248.5

CKDⁱ

29.6% (n = 673)

-

1.5% (n = 43)

-

PGS^j (eGFR_crea, unweighted)

627.8 ± 15.2

579.7, 679.0

626.4 ± 14.8

571.9, 681.1

PGS^k (eGFR_cys, unweighted)

204.6 ± 8.8

175.8, 229.1

204.5 ± 8.7

173.2, 235.2

PGS^j (eGFR_crea, weighted)

614.7 ± 14.0

561.0, 661.5

613.2 ± 13.3

565.9, 665.9

PGS^k (eGFR_cys, weighted)

212.2 ± 8.5

179.7, 238.7

212.2 ± 8.4

181.3, 245.5