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Fig. 5 | BMC Genomic Data

Fig. 5

From: Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly – comparative results from the KORA and AugUR study

Fig. 5

Scheme for calculation of explained eGFR variance by PGS. We computed the association of the PGS with eGFR residuals adjusted for age and sex in KORA S4 (n = 2,900, general adults) and AugUR (n = 2,272, elderly) via linear regression. Shown are the PGS-explained variance of eGFRcrea and eGFRcys (R2) and the three components that drive the R2-values (relative genetic effect): PGS variance, beta-coefficient of the PGS-association with eGFR (absolute genetic effect), age-/sex adjusted eGFR variance

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