Fig. 5From: Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly – comparative results from the KORA and AugUR studyScheme for calculation of explained eGFR variance by PGS. We computed the association of the PGS with eGFR residuals adjusted for age and sex in KORA S4 (n = 2,900, general adults) and AugUR (n = 2,272, elderly) via linear regression. Shown are the PGS-explained variance of eGFRcrea and eGFRcys (R2) and the three components that drive the R2-values (relative genetic effect): PGS variance, beta-coefficient of the PGS-association with eGFR (absolute genetic effect), age-/sex adjusted eGFR varianceBack to article page