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Fig. 4 | BMC Genomic Data

Fig. 4

From: Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly – comparative results from the KORA and AugUR study

Fig. 4

Frequencies of the eGFR-lowering alleles that are part of the PGS in the general adults compared to the elderly. Shown are the frequencies of the eGFR lowering alleles that are part of PGS_eGFRcrea (A) or PGS_eGFRcys (B) in the general adults (KORA, n = 2,272, y-axis) versus the elderly (AugUR, n = 2,900, x-axis). Here, we focused on the variants with high imputation quality (r.2 > 0.8; 534 in the PGS_eGFRcrea, 186 in the PGS_eGFRcys). We tested the allele frequencies for difference between the two studies (Chi-square test); color codes no (black), nominal (blue), or Bonferroni-corrected significance (red) of the difference (pdiff < 0.05/534 for variants in the PGS_eGFRcrea and pdiff < 0.05/186 for the variants in the PGS_eGFRcys)

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