Table 2 Major drugs recognized via use of the L1000FWD database
Rank | Drug | Similarity Score | P-value | Q-value | Z-score | Combined Score | MOA |
|---|---|---|---|---|---|---|---|
1 | KM-03949SC | -0.4907 | 1.23e-66 | 1.06e-62 | 1.80 | -118.88 | MEK inhibitor |
2 | RJC-00245SC | -0.4352 | 1.37e-53 | 1.15e-50 | 1.73 | -91.41 | estrogen receptor agonist |
3 | BRD-K82185908 | -0.4352 | 1.99e-51 | 1.29e-48 | 1.75 | -88.74 | adrenergic receptor antagonist |
4 | KM-00519SC | -0.4259 | 3.78e-52 | 2.53e-49 | 1.72 | -88.55 | RAF inhibitor |
5 | BRD-K94987138 | -0.4167 | 6.71e-51 | 3.99e-48 | 1.73 | -86.64 | histamine receptor antagonist |
6 | BRD-K67619794 | -0.4074 | 3.33e-49 | 1.53e-46 | 1.85 | -89.77 | histamine receptor antagonist |
7 | BRD-K05197617 | -0.4074 | 5.57e-49 | 2.46e-46 | 1.73 | -83.71 | EGFR inhibitor |
8 | Ivermectin | -0.3611 | 7.32e-40 | 1.20e-37 | 1.87 | -73.29 | benzodiazepine receptor agonist |
9 | Vemurafenib | -0.3426 | 1.96e-36 | 2.20e-34 | 1.81 | -64.68 | RAF inhibitor |
10 | BRD-K03122949 | -0.3426 | 1.44e-36 | 1.64e-34 | 1.74 | -62.28 | dopamine receptor antagonist |