Fig. 1

Identification of PTR (A) analysis steps performed, from sequence alignment to PTR detection to assessment of potential impact of tandem repeats present in the protein structures, are shown. B PTR allele variations with numbers of each variant are shown. Horizontal axis shows the allele type, positive = expansion; negative = contraction whereas vertical axis shows the number (log10-transformation). C number of PTR alleles are plotted against their TMscore, darker horizontal bar shows the number of alleles with score less than 0.3. D Assessment of PTR alleles impact of Sirt3 protein model, right, predicted protein model, left, protein folding upon the presence of PTR allele NQPTNQPT (shown in brown color and underlined in the sequence box below). Alternative folding of templates (TMscore = 0.24) is impacted by the PTR allele present in 58 strains. Two boxes below show the reference allele and PTR allele motif