Gene symbols | Type | Degree | Full name | Encoded protein function |
---|---|---|---|---|
IGF1 | up | 24 | Insulin-like growth factor 1 | The encoded protein is a member of a family of proteins involved in mediating growth and development |
BMP4 | up | 23 | Bone morphogenetic protein 4 | The encoded protein is possibly involved in the pathology of multiple cardiovascular diseases and human cancers |
SPP1 | up | 22 | Secreted phosphoprotein 1 | The encoded protein is a cytokine that upregulates the expression of interferon-É£ and interleukin-12 |
APOB | down | 22 | Apolipoprotein B | The encoded protein affects plasma cholesterol and apolipoprotein levels in various diseases |
CCND1 | up | 20 | Cyclin D1 | The encoded protein alters cell cycle progression, and its expression is widely observed in various human cancers |
CD44 | up | 18 | CD44 molecule | The encoded protein participates in various cellular functions, including lymphocyte activation, recirculation, and homing; hematopoiesis; and tumor metastasis |
PTGS2 | up | 18 | Prostaglandin-endoperoxide synthase 2 | The encoded protein is responsible for activating prostanoid biosynthesis involved in inflammation and mitogenesis |
CFTR | down | 16 | CF transmembrane conductance regulator | The encoded protein acts as a chloride channel, and it controls ion and water secretion and absorption in epithelial tissues |
BMP2 | down | 16 | Bone morphogenetic protein 2 | The encoded protein plays a role in bone and cartilage development |
KLF4 | down | 14 | Kruppel-like factor 4 | The encoded protein controls the G1-to-S transition of the cell cycle following DNA damage by mediating the expression of the tumor suppressor gene p53 |
TLR2 | up | 14 | Toll-like receptor 2 | The encoded protein regulates host inflammation and promotes apoptosis in response to exposure to bacterial lipoproteins |