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Table1 Detailed information about the hub gene

From: Identification of hub genes and pathways in colitis-associated colon cancer by integrated bioinformatic analysis

Gene symbols

Type

Degree

Full name

Encoded protein function

IGF1

up

24

Insulin-like growth factor 1

The encoded protein is a member of a family of proteins involved in mediating growth and development

BMP4

up

23

Bone morphogenetic protein 4

The encoded protein is possibly involved in the pathology of multiple cardiovascular diseases and human cancers

SPP1

up

22

Secreted phosphoprotein 1

The encoded protein is a cytokine that upregulates the expression of interferon-É£ and interleukin-12

APOB

down

22

Apolipoprotein B

The encoded protein affects plasma cholesterol and apolipoprotein levels in various diseases

CCND1

up

20

Cyclin D1

The encoded protein alters cell cycle progression, and its expression is widely observed in various human cancers

CD44

up

18

CD44 molecule

The encoded protein participates in various cellular functions, including lymphocyte activation, recirculation, and homing; hematopoiesis; and tumor metastasis

PTGS2

up

18

Prostaglandin-endoperoxide synthase 2

The encoded protein is responsible for activating prostanoid biosynthesis involved in inflammation and mitogenesis

CFTR

down

16

CF transmembrane conductance regulator

The encoded protein acts as a chloride channel, and it controls ion and water secretion and absorption in epithelial tissues

BMP2

down

16

Bone morphogenetic protein 2

The encoded protein plays a role in bone and cartilage development

KLF4

down

14

Kruppel-like

factor 4

The encoded protein controls the G1-to-S transition of the cell cycle following DNA damage by mediating the expression of the tumor suppressor gene p53

TLR2

up

14

Toll-like receptor 2

The encoded protein regulates host inflammation and promotes apoptosis in response to exposure to bacterial lipoproteins