Table 1 PAM motifs according to CRISPR-Cas type but regardless of the contained phages

II-A

I-C

IV

Streptococcus pyogenes

S. agalactiae

Listeria monocytogenes

Francisella novicida (FnCas9)

NGG

NAG

(A/T)GG

[7, 16, 17]

NGG

[18]

II-A

Staphylococcus aureus

NGRRT

NGRRN

NNGRRT

TTGGGT

[19,20,21]

II- C

Neisseria meningitidis

NNNNGATT

[16]

II-A

Streptococcus thermophilus

NNAGAAW

NGGNG

[16, 17, 22, 23]

V-A

II-A

Lachnospiraceae bacterium

TTTV

TCTA

[24]

V-A Cas12a

(AsCas12a, AsCpf1)

Acidaminococcus sp.

GTTV

GCTV

TATA (eng. Cpf1)

TTTV

[10, 25]

I-E

Escherichia coli

C(T/A)T

[17, 26, 27]

I-E

Escherichia coli

5’-ATG-3’

5’-AAG-3’

Its complement

5′-CTT-3′

[28, 29]

I-E

Escherichia coli

AWG

[30]

I-A

S. solfataricus

TCN

CCN

[31,32,33]