Fig. 1
From: Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
a The SARS-CoV-2 polyproteins pp1a and pp1ab. pp1a contains Nsp1-Nsp11, pp1ab contains Nsp1-Nsp16 with Nsp11 skipped by a − 1 ribosomal frameshift. Nsp5 and its cleavage sites are indicated with red arrows. Nsp3 cleavage sites are indicated with grey arrows. b SARS-CoV-2 native Nsp5 cleavage motifs. NetCorona scores are indicated, and residues in white boxes differ from SARS-CoV. c SARS-CoV-2 pp1ab sequences scored with NetCorona. Scores and frequency were determined for all P5-P4’ motifs surrounding glutamine residues in 8017 patient-derived SARS-CoV-2 sequences. Known Nsp5 cleavage sites are indicated in green, while mutations at a Nsp5 cleavage site are indicated in blue. The Nsp5-Nsp6 cleavage site is indicated in red, and all other glutamine motifs are indicated in black